Paramythiotis D, Kofina K, Bangeas P, Tsiompanou F, Karayannopoulou G, Basdanis G. Solitary fibrous tumor of the pancreas: Case report and review of the literature. World J Gastrointest Surg 2016; 8(6): 461-466 [PMID: 27358679 DOI: 10.4240/wjgs.v8.i6.461]
Corresponding Author of This Article
Daniel Paramythiotis, MD, MSc, PhD, Assistant Professor of Surgery, 1st Propedeutic Surgical Clinic, A.H.E.P.A. University Hospital, Aristotle’s University of Thessaloniki, L. Tzavella 2D, Pilea, 54636 Thessaloniki, Greece. danosprx1@hotmail.com
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jun 27, 2016; 8(6): 461-466 Published online Jun 27, 2016. doi: 10.4240/wjgs.v8.i6.461
Solitary fibrous tumor of the pancreas: Case report and review of the literature
Daniel Paramythiotis, Konstantinia Kofina, Petros Bangeas, Fani Tsiompanou, Georgia Karayannopoulou, George Basdanis
Daniel Paramythiotis, Konstantinia Kofina, Petros Bangeas, George Basdanis, 1st Propedeutic Surgical Clinic, A.H.E.P.A. University Hospital, Aristotle’s University of Thessaloniki, 54636 Thessaloniki, Greece
Fani Tsiompanou, Georgia Karayannopoulou, Department of Pathology, Aristotle’s University of Thessaloniki, 54636 Thessaloniki, Greece
Author contributions: Paramythiotis D and Basdanis G designed the report; Kofina K analyzed the data and wrote the paper; Bangeas P collected the patient’s clinical data; Tsiompanou F and Karayannopoulou G performed the histological examination.
Institutional review board statement: This case report was approved by the A.H.E.P.A. University Hospital Institutional Review Board.
Informed consent statement: The patient provided informed consent prior to the review.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Daniel Paramythiotis, MD, MSc, PhD, Assistant Professor of Surgery, 1st Propedeutic Surgical Clinic, A.H.E.P.A. University Hospital, Aristotle’s University of Thessaloniki, L. Tzavella 2D, Pilea, 54636 Thessaloniki, Greece. danosprx1@hotmail.com
Telephone: +30-6944-906619 Fax: +30-2310-994784
Received: June 28, 2015 Peer-review started: July 11, 2015 First decision: August 24, 2015 Revised: March 1, 2016 Accepted: March 17, 2016 Article in press: March 18, 2016 Published online: June 27, 2016 Processing time: 357 Days and 22.8 Hours
Abstract
Solitary fibrous tumor (SFT) is a mesenchymal tumor typically located in the pleura, but can also be found as an asymptomatic mass in other areas, including the liver, peritoneum, kidney and salivary glands. However, SFT rarely locates in the pancreas. We present such a case of pancreatic SFT, along with a review of all reported cases. A 55-year-old man was treated surgically for an asymptomatic pancreatic mass after a rigorous preoperative control. Histologic examination of the resected specimen showed characteristics of an SFT. As only 15 cases of pancreatic SFT have been reported so far, an attempt to compare the cases was considered intriguing. We found that patients with pancreatic SFT were mainly women (81.25%), with a median age of 54 years at the time of diagnosis and a median tumor size of 5.83 cm. Pancreatic SFTs were revealed incidentally in 50% of cases, and all of them showed an enhancement through arterial computed tomography. All tumors were positive for CD34, ten were positive for Bcl-2, and twelve were negative for S100. The diagnosis of this pancreatic tumor is established by a combination of clinical suspicion, imaging procedures and histological findings, and is confirmed by immunohistochemical staining. Although the behavior of SFTs is rather benign, close clinical follow-up is recommended due to a potentially malignant nature.
Core tip: Solitary fibrous tumor (SFT) is a mesenchymal tumor that rarely locates in the pancreas. We present the case of a 55-year-old man with a pancreatic lesion that proved to be an SFT after thorough pre- and post-operative control. The characteristics of this case and the other fifteen cases of pancreatic SFT reported in the literature are described.
