Efficacy of endoscopic submucosal dissection in the treatment of early gastrointestinal lesions

doi:10.4240/wjgs.v18.i2.112776

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 2

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (0)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-8) series.

Item

Count

PDF

HTML

Figures (1-2)

Tables (1-8)

Sum=13

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=5

Feb 27, 2026 (publication date) through Feb 26, 2026

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Surgery

ISSN

1948-9366

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Feb 27, 2026; 18(2): 112776
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.112776

Efficacy of endoscopic submucosal dissection in the treatment of early gastrointestinal lesions

Ying Ling, Jun Wang, Chun-Hui Xi, Juan Liu

Ying Ling, Jun Wang, Chun-Hui Xi, Juan Liu, Digestive Endoscopy Center, Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China

Ying Ling, Jun Wang, Chun-Hui Xi, Juan Liu, Sichuan Branch of National Clinical Research Center for Digestive Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China

Author contributions: Ling Y and Liu J were involved in the conception, design, analysis, and interpretation of the data; Wang J contributed to drafting of the paper, revising it critically for intellectual content; Xi CH contributed to the final approval of the version to be published. All authors agree to be accountable for all aspects of the work.

Institutional review board statement: This study was approved by the Medicine Ethics Committee of Affiliated Hospital of North Sichuan Medical College.

Informed consent statement: Informed consent was waived because the research involved retrospective analysis of anonymized data and posed no risk to patients, in accordance with ethical guidelines for retrospective studies.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Corresponding author: Juan Liu, Associate Chief Physician, Digestive Endoscopy Center, Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan South Road, Shunqing District, Nanchong 637000, Sichuan Province, China. lingying838587@126.com

Received: September 23, 2025
Revised: October 27, 2025
Accepted: December 11, 2025
Published online: February 27, 2026
Processing time: 155 Days and 23.4 Hours

Abstract

BACKGROUND

Endoscopic submucosal dissection (ESD) is applicable to early-stage gastrointestinal cancers, but its role in early gastrointestinal lesions is insufficiently researched.

AIM

To evaluated the efficacy and safety profile of ESD compared with conventional gastrectomy for managing early gastrointestinal lesions, emphasizing clinical outcomes and postoperative recovery.

METHODS

A retrospective review was conducted on 206 patients diagnosed with early-stage gastrointestinal lesions at the Affiliated Hospital of North Sichuan Medical College between June 2021 and June 2024. Patients were divided into two groups: 98 underwent gastrectomy and 108 received ESD. Outcomes assessed included overall treatment efficacy, postoperative complications, serum tumor marker levels, gastrointestinal hormone concentrations, and mucosal barrier integrity indices.

RESULTS

The ESD group showed higher overall treatment efficacy (98.15% vs 92.86%; P > 0.05) and a significant lower complication rate (5.56% vs 13.27%). ESD was also associated with reduced intraoperative blood loss (58.36 mL vs 60.31 mL; P < 0.001) and shorter operative durations (69.21 minutes vs 69.86 minutes; P = 0.001). Gastrointestinal function recovered more rapidly following ESD, with an earlier return to oral intake (2.43 days vs 2.65 days; P = 0.006). Preoperatively, ESD patients exhibited lower thymidine kinase 1 and D-lactate levels, indicating enhanced preservation of mucosal integrity.

CONCLUSION

For early gastrointestinal lesions, ESD represents a safe and effective alternative to conventional gastrectomy. It enables precise lesion excision with fewer complications and faster postoperative recovery.

Keywords: Efficacy; Endoscopic submucosal dissection; Early gastrointestinal lesions; Gastrointestinal cancer; Postoperative complications

Core Tip: This study compared endoscopic submucosal dissection and conventional gastrectomy in 206 patients with early gastrointestinal lesions. The findings demonstrate endoscopic submucosal dissection significant clinical advantages, including reduced intraoperative bleeding, shorter operative time, and faster postoperative recovery. This study carries clinical implications, establishing endoscopic submucosal dissection as a preferred treatment option that can significantly reduce surgical trauma, shorten the perioperative process, and promote the rapid recovery of patients with early gastrointestinal lesions.