Guo Q, Lu HY, Lyu H, Tian H, Zhao Q, Zheng YC. Complete appendiceal intussusception and appendiceal mucinous tumor: A case report and review of literature. World J Gastrointest Surg 2025; 17(9): 109320 [DOI: 10.4240/wjgs.v17.i9.109320]
Corresponding Author of This Article
Yang-Chun Zheng, MD, Research Assistant Professor, Department of Colorectal Surgery, Sichuan Cancer Hospital, No. 55 Section 4, Renmin South Road, Chengdu 610041, Sichuan Province, China. zheng_ych@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Qi Guo, Hua Lyu, Qiang Zhao, Department of Gastrointestinal Surgery, Ya'an People's Hospital, Ya'an 625000, Sichuan Province, China
Han-Ying Lu, Department of General Medicine, Ya’an People's Hospital, Ya'an 625000, Sichuan Province, China
Hao Tian, Department of Gastrointestinal Surgery, Wenzhou District People's Hospital, Wenzhou 621000, Sichuan Province, China
Yang-Chun Zheng, Department of Colorectal Surgery, Sichuan Cancer Hospital, Chengdu 610041, Sichuan Province, China
Author contributions: Guo Q and Lu HY drafted the manuscript and collected the data; Lu H and Tian H analyzed, organized and conducted clinical diagnosis and treatment of the data; Zhao Q and Zheng YC guided the operation and revised the manuscript; all authors have read and agreed to the published version of the manuscript.
Informed consent statement: Informed written consent was obtained from the patient’s next of kin for the publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yang-Chun Zheng, MD, Research Assistant Professor, Department of Colorectal Surgery, Sichuan Cancer Hospital, No. 55 Section 4, Renmin South Road, Chengdu 610041, Sichuan Province, China. zheng_ych@163.com
Received: May 8, 2025 Revised: June 8, 2025 Accepted: July 18, 2025 Published online: September 27, 2025 Processing time: 140 Days and 6.4 Hours
Abstract
BACKGROUND
Complete appendiceal intussusception (CAI) coexisting with appendiceal tumor represents an exceptionally rare clinical tumor. This study presented a retrospective analysis of a case involving CAI complicated by appendiceal mucinous tumor, supplemented by a review of 10 previously reported cases to distill diagnostic and therapeutic insights.
CASE SUMMARY
A 74-year-old male patient presented with abdominal pain. Abdominal contrast-enhanced computed tomography (CECT) initially suggested a colonic tumor with intussusception. Colonoscopy identified a mass in the colon 60 cm from the anus. Intraoperative exploration confirmed CAI secondary to an appendiceal neoplasm. The patient underwent laparoscopic right hemicolectomy with regional lymphadenectomy under general anesthesia. Postoperative recovery was uneventful, and the patient was discharged 9 days post-surgery. Twelve-month follow-up revealed no evidence of recurrence or metastasis.
CONCLUSION
Plain abdominal computed tomography may underestimate the presence of CAI and appendiceal mucinous tumor, whereas CECT significantly improves diagnostic accuracy. Preoperative suspicion of appendiceal malignancy should be entertained in cases of CAI. In the absence of definitive biopsy results, intraoperative frozen section analysis is recommended to guide radical resection.
Core Tip: Complete appendiceal intussusception (CAI) and appendiceal mucinous adenocarcinoma (AMA) is an extremely rare condition, which has not been reported in PubMed, and the preoperative diagnosis of this disease lacks specificity and is very easy to misdiagnose. This article summaries the clinical experience and lessons learned for the diagnosis and management of this disease. The main contributions include: (1) Novelty or clinical significance: First reported case of CAI and AMA in PubMed; (2) Educational value, providing insight into the diagnostic pitfalls and surgical decisions of CAI and AMA; and (3) A definite preoperative diagnosis can avoid secondary surgery.
