Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.111943
Revised: August 4, 2025
Accepted: September 3, 2025
Published online: October 27, 2025
Processing time: 97 Days and 17.9 Hours
Muco-submucosal elongated polyps (MSEPs) are rare benign gastrointestinal lesions, typically reported in the colon and seldom observed in the small intestine. These polyps are generally slow-growing and asymptomatic, making diagnosis and management challenging. Rapid enlargement of MSEPs in the duodenum is particularly rare and may raise suspicion for neoplastic potential.
We report the case of a 64-year-old female who presented with nausea and abdominal pain. Abdominal computed tomography revealed a soft tissue density in the descending duodenum. Upper endoscopy performed 15 months earlier had identified a 1.5-cm mucosal elevation in the second portion of the duodenum. On follow-up endoscopy, the lesion had enlarged significantly into a 10-cm elon
Although MSEPs are typically benign, our case demonstrates that rapid growth may occur. This highlights the importance of continued endoscopic surveillance and early intervention, even in asymptomatic patients, to prevent potential com
Core Tip: Muco-submucosal elongated polyps (MSEPs) are rare benign gastrointestinal lesions, typically found in the colon and infrequently in the small intestine. We report a case of a rapidly enlarging MSEP in the duodenum, which expanded from a 1.5-cm mucosal elevation to a 10-cm pedunculated lesion within 15 months. Complete en bloc resection was achieved by endoscopic submucosal dissection, and histology confirmed the diagnosis. This case highlights the potential for rapid growth of duodenal MSEPs and emphasizes the importance of regular endoscopic surveillance, even in patients without symptoms.