Yang Y, Zhong DF. Unusually rapid growth of a duodenal muco-submucosal elongated polyp: A case report. World J Gastrointest Surg 2025; 17(10): 111943 [DOI: 10.4240/wjgs.v17.i10.111943]
Corresponding Author of This Article
Yi Yang, MD, Department of Gastroenterology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua People's Hospital, No. 267 Danxi East Road, Jindong District, Jinhua 321000, Zhejiang Province, China. yangyi_0325@163.com
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Gastroenterology & Hepatology
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Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 27, 2025 (publication date) through Oct 24, 2025
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World Journal of Gastrointestinal Surgery
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1948-9366
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Yang Y, Zhong DF. Unusually rapid growth of a duodenal muco-submucosal elongated polyp: A case report. World J Gastrointest Surg 2025; 17(10): 111943 [DOI: 10.4240/wjgs.v17.i10.111943]
World J Gastrointest Surg. Oct 27, 2025; 17(10): 111943 Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.111943
Unusually rapid growth of a duodenal muco-submucosal elongated polyp: A case report
Yi Yang, Ding-Fu Zhong
Yi Yang, Ding-Fu Zhong, Department of Gastroenterology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua People's Hospital, Jinhua 321000, Zhejiang Province, China
Author contributions: Yang Y helped write and edit the manuscript and collect data; Zhong DF helped write the paper; all the authors have read and approved the content of the manuscript.
Informed consent statement: Written informed consent was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi Yang, MD, Department of Gastroenterology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua People's Hospital, No. 267 Danxi East Road, Jindong District, Jinhua 321000, Zhejiang Province, China. yangyi_0325@163.com
Received: July 21, 2025 Revised: August 4, 2025 Accepted: September 3, 2025 Published online: October 27, 2025 Processing time: 97 Days and 11.7 Hours
Abstract
BACKGROUND
Muco-submucosal elongated polyps (MSEPs) are rare benign gastrointestinal lesions, typically reported in the colon and seldom observed in the small intestine. These polyps are generally slow-growing and asymptomatic, making diagnosis and management challenging. Rapid enlargement of MSEPs in the duodenum is particularly rare and may raise suspicion for neoplastic potential.
CASE SUMMARY
We report the case of a 64-year-old female who presented with nausea and abdominal pain. Abdominal computed tomography revealed a soft tissue density in the descending duodenum. Upper endoscopy performed 15 months earlier had identified a 1.5-cm mucosal elevation in the second portion of the duodenum. On follow-up endoscopy, the lesion had enlarged significantly into a 10-cm elongated, pedunculated polyp. Endoscopic submucosal dissection was performed for complete en bloc resection. Histopathology confirmed the diagnosis of a MSEP, with no evidence of malignancy. Surveillance endoscopy performed one year after resection showed no recurrence.
CONCLUSION
Although MSEPs are typically benign, our case demonstrates that rapid growth may occur. This highlights the importance of continued endoscopic surveillance and early intervention, even in asymptomatic patients, to prevent potential complications and ensure timely diagnosis.
Core Tip: Muco-submucosal elongated polyps (MSEPs) are rare benign gastrointestinal lesions, typically found in the colon and infrequently in the small intestine. We report a case of a rapidly enlarging MSEP in the duodenum, which expanded from a 1.5-cm mucosal elevation to a 10-cm pedunculated lesion within 15 months. Complete en bloc resection was achieved by endoscopic submucosal dissection, and histology confirmed the diagnosis. This case highlights the potential for rapid growth of duodenal MSEPs and emphasizes the importance of regular endoscopic surveillance, even in patients without symptoms.
