Association between prediabetes and higher risk of mortality following acute ischemic stroke: A meta-analysis

Table 1 Comprehensive overview of all studies included for meta-analysis

Ref.	Type of study	Total sample size (n)	Sample size (n): Prediabetics with ischemic stroke	Age (years) (mean ± SD)	Male sex		Median follow-up (months)	Definition of prediabetes
					n	%
Tanaka et al[3], 2013, Japan	Cohort	116	52	67.8 ± 11.7	36	69.2	1	FPG ≤ 126 mg/dL; oral glucose tolerance test: 140-199 mg/dL
Jia et al[11], 2014, China	Cohort	926	439	63.2 ± 12.6	290	66.1	12	FPG: 6.1-7.0 mmol/L and 2-hour post-prandial glucose: 7.8-11.1 mmol/L
Roquer et al[15], 2014, Spain	Case-control	1088	273	771	135	49.5	3	PG: 5.7-6.4 mmol/L
Wu et al[16], 2014, China	Case-control	1810	507	63 ± 12	331	65.3	12	HBA1c < 5.5% and 5.5%-6.1%
Ernaga Lorea et al[2], 2017, Spain	Cohort	255	72	73.91	148	58	30	HBA1c: 5.7%-6.4%
Kim et al[13], 2017, South Korea	Cohort	499239	81875	49.7 ± 11.92 51.3 ± 12.23	-	60.72 64.93	132	PG: 100-125 mg/dL
Osei et al[14], 2017, Netherlands	Case-control	1007	176	65 ± 14	-	-	-	PG: 5.6-6.9 mmol/L
Zhu et al[17], 2017, China	Cohort	3882	412	63.1 ± 10.8	270	65.5	3	PG: 6.1-7.0 mmol/L
Ago et al[9], 2018, Japan	Case-control	4655	4655	70.3 ± 12.4	2962	63.5	3	-
Forti et al[10], 2020, Italy	Cohort	2662	830	79 (71-85)1	360	43.4	1	HBA1c: 5.7%-6.4%
Kim et al[12], 2021, South Korea	Cohort	661	197	68.7 ± 12.6	115	58.4	12	HBA1c: 5.7%-6.4%

¹Median age with or without range.

²Impaired fasting glucose (IFG) stage 1 [fasting plasma glucose (FPG): 100-110 mg/dL].

³IFG stage 2 (FPG: 110-125 mg/dL).

FPG: Fasting plasma glucose; HBA1c: Hemoglobin A1c; PG: Plasma glucose.