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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jan 15, 2026; 17(1): 110528
Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.110528
Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.110528
Association between prediabetes and higher risk of mortality following acute ischemic stroke: A meta-analysis
Bhavin Patel, Department of Internal Medicine, Trinity Health Oakland Hospital, Pontiac, MI 48341, United States
Kshitij Mahajan, Department of Internal Medicine, Trinity Health Oakland/Wayne State University, Pontiac, MI 48341, United States
Arankesh Mahadevan, Department of Neurology, University of Utah Health, Salt Lake City, UT 84132, United States
Rishika Trivedi, Department of Internal Medicine, DHR Health, Edinburg, TX 78539, United States
Avleen Dhingra, Department of Medicine, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India
Samrath Singh Brar, Department of Internal Medicine, Trinity Health Livonia Hospital, Livonia, MI 48154, United States
Sakshi Dixit, Department of Internal Medicine, Cleveland Clinic Akron General Medical Center, Akron, OH 44307, United States
Rupak Desai, Outcomes Research, Independent Researcher, Atlanta, GA 30033, United States
Co-corresponding authors: Arankesh Mahadevan and Rupak Desai.
Author contributions: Patel B and Mahajan K acquired and curated data; Patel B, Mahajan K and Desai R conceived and designed the study; Mahadevan A, Trivedi R and Dhingra A drafted the manuscript; Mahadevan A and Desai R drafted the manuscript, performed formal analysis, provided resources and supervision as the co-corresponding authors; Brar SS and Dixit S performed verification; all authors reviewed and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this work.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rupak Desai, MBBS, Outcomes Research, Independent Researcher, Scottdale, Atlanta, GA 30033, United States. drrupakdesai@gmail.com
Received: June 9, 2025
Revised: September 19, 2025
Accepted: November 12, 2025
Published online: January 15, 2026
Processing time: 220 Days and 1.9 Hours
Revised: September 19, 2025
Accepted: November 12, 2025
Published online: January 15, 2026
Processing time: 220 Days and 1.9 Hours
Core Tip
Core Tip: This meta-analysis synthesizes 11 studies (> 84000 participants) evaluating whether prediabetes is associated with mortality after acute ischemic stroke. Unadjusted results were heterogeneous; however, adjusted analyses showed a significant association between prediabetes and higher poststroke mortality. These findings support early identification of prediabetes after stroke and emphasize rigorous secondary prevention while definitive interventional studies are pursued.