Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelial-mesenchymal transition

doi:10.4239/wjd.v16.i5.102196

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May 15, 2025 (publication date) through Oct 24, 2025

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. May 15, 2025; 16(5): 102196
Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.102196

Table 1 Main characteristics of the animals

Item	Control	Model vs control	SFSGs vs model
Physiological attributes
Body weight	Normal	Decrease	-
Src	Normal	Increase	Decrease
BUN	Normal	Increase	Decrease
Albuminuria	Normal	Increase	Decrease
ACR	Normal	Increase	Decrease
Urine volume	Normal	Increase	-
Blood glucose	Normal	Increase	-
Pathological attributes
Glomerulosclerosis	Normal	Increase	Decrease
Glomerular fibrosis	Normal	Increase	Decrease
Glycocaly depth	Normal	Decrease	Increase

Src: Serum creatinine; BUN: Blood urea nitrogen; ACR: Albumin/urine creatinine ratio; SFSGs: Shenfushu granules.

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Citation: Yang XD, Ma SJ, Xiang DX, Yang YY. Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelial-mesenchymal transition. World J Diabetes 2025; 16(5): 102196
URL: https://www.wjgnet.com/1948-9358/full/v16/i5/102196.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i5.102196