Impact of visceral adiposity on glycemic variability in patients with insulin-treated type 2 diabetes undergoing hemodialysis

Figure 1 Glycemic profiles during hemodialysis and non-hemodialysis days in patients stratified by glycemic variability. ^aP < 0.001 for differences in time in range (ΔTIR) < 5% vs ΔTIR > 5% at nighttime glycemia on hemodialysis days; ^bP < 0.05 for ΔTIR < 5% vs ΔTIR > 5% at daytime glycemia on non-hemodialysis days; ^cP < 0.05 for ΔTIR < 5% vs ΔTIR > 5% at nighttime glycemia on non-hemodialysis days. CGM: Continuous glucose monitoring; Glyc-HD: Glycemia during hemodialysis; GlycNight-HD: Nighttime glycemia on hemodialysis days; GlycOffHD-Day: Daytime glycemia on non-hemodialysis days; GlycOffHD-Night: Nighttime glycemia on non-hemodialysis days; Glyc3hPost-HD: Glycemia 3 hours post-hemodialysis; GlycPre-HD: Glycemia before hemodialysis; HD: Hemodialysis; ΔTIR: Differences in time in range.

Figure 2 Receiver operating characteristic curve to determinate the cutoff of visceral fat area and glycemic variability. According to the coordinates of the curve, a visceral fat area threshold of approximately 63 cm² provided the best balance between sensitivity (88%) and specificity (67%). ROC: Receiver operating characteristic.