Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Diabetes. Mar 15, 2026; 17(3): 116660
Published online Mar 15, 2026. doi: 10.4239/wjd.v17.i3.116660
Published online Mar 15, 2026. doi: 10.4239/wjd.v17.i3.116660
Recurrent hypoglycemia in a young female with nesidioblastosis: A case report and review of literature
Shyam Bavaria, Amarpreet Chana, Khulud Mahmood Nurani, Joshua Kimang’a, School of Medicine, University of Nairobi, Nairobi 30197-00100, Kenya
Author contributions: Bavaria S identified the case; Bavaria S, Chana A, Nurani KM and Kimang’a J drafted the case report.
Informed consent statement: Written informed consent was sought from the patient in line with ethical standards at the hospital.
Conflict-of-interest statement: The authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Khulud Mahmood Nurani, School of Medicine, University of Nairobi, Mbagathi Road, Nairobi 30197-00100, Kenya. khuludnurani@gmail.com
Received: November 17, 2025
Revised: January 10, 2026
Accepted: February 5, 2026
Published online: March 15, 2026
Processing time: 115 Days and 13.4 Hours
Revised: January 10, 2026
Accepted: February 5, 2026
Published online: March 15, 2026
Processing time: 115 Days and 13.4 Hours
Core Tip
Core Tip: Adult-onset nesidioblastosis is an uncommon but important cause of endogenous hyperinsulinism that can mimic insulinoma and lead to years of misdiagnosis. This case illustrates how persistent hypoglycemia despite standard medical therapy should prompt consideration of rare etiologies and the use of advanced imaging, such as 68Ga-DOTATOC positron emission tomography/computed tomography, when conventional studies are non-localizing. Early recognition improves the likelihood of timely surgical management and prevents prolonged morbidity.