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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jan 15, 2026; 17(1): 111808
Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.111808
Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.111808
Association of serum and vitreous homocysteine and uric acid concentrations with post-vitrectomy prognosis in patients with proliferative diabetic retinopathy
Qi-Bo Ran, Chun-Yan Lei, Sheng Gao, Xiang-Gang Yang, Fei-Peng Jiang, Mei-Xia Zhang, Department of Ophthalmology and Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Co-first authors: Qi-Bo Ran and Chun-Yan Lei.
Author contributions: Ran QB, Lei CY, and Zhang MX designed the research study; Gao S, Yang XG, and Jiang FP performed the research; Ran QB and Lei CY analyzed the data and wrote the manuscript. All authors have read and approved the final manuscript.
Supported by the Sichuan Provincial Science and Technology Support Project, No. 2024YFFK0303.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the West China Hospital of Sichuan University, No. 2020 (834).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data will be made available on reasonable request from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mei-Xia Zhang, MD, Chief Physician, Professor, Department of Ophthalmology and Research Laboratory of Macular Disease, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. zhangmeixia@scu.edu.cn
Received: July 10, 2025
Revised: September 20, 2025
Accepted: December 2, 2025
Published online: January 15, 2026
Processing time: 188 Days and 17.6 Hours
Revised: September 20, 2025
Accepted: December 2, 2025
Published online: January 15, 2026
Processing time: 188 Days and 17.6 Hours
Core Tip
Core Tip: This study demonstrates that vitreous homocysteine and uric acid are significantly elevated in patients with proliferative diabetic retinopathy, reflecting localized ocular pathology. Unlike their serum counterparts, elevated vitreous homocysteine specifically correlates with worse early visual acuity, progressive retinal nerve fiber layer thinning, and delayed microvascular impairment after pars plana vitrectomy, positioning it as a superior, compartment-specific predictor of multidimensional postoperative outcomes.