Progress in the application of mesenchymal stem cells to attenuate apoptosis in diabetic kidney disease

doi:10.4239/wjd.v16.i6.105711

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jun 15, 2025; 16(6): 105711
Published online Jun 15, 2025. doi: 10.4239/wjd.v16.i6.105711

Progress in the application of mesenchymal stem cells to attenuate apoptosis in diabetic kidney disease

Ping Nie, Wei Qin, Wei-Chen Nie, Bing Li

Ping Nie, Wei Qin, Bing Li, Department of Nephropathy, The Second Hospital of Jilin University, Changchun 130041, Jilin Province, China

Wei-Chen Nie, Basic Clinical Specialization in Integrative Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China

Author contributions: Nie P wrote the original draft; Qin W made the diagrams; Nie WC searched for information; Li B offered recommendations for improvement; All the prepared collaboratively the draft, and consented to the submitted version.

Supported by Science and Technology Research Program of Jilin Provincial Department of Education, No. JJKH20231218KJ; and Project of the Jilin Provincial Administration of Traditional Chinese Medicine, No. 2024111.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Bing Li, Department of Nephropathy, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, Jilin Province, China. li_bing2020@jlu.edu.cn

Received: February 17, 2025
Revised: March 24, 2025
Accepted: April 25, 2025
Published online: June 15, 2025
Processing time: 117 Days and 8.6 Hours

Core Tip

Core Tip: Diabetic kidney disease (DKD) represents a prevalent and serious complication of diabetes. Mesenchymal stem cells (MSCs) and their extracellular vesicles (MSC-EVs) show promise for treating DKD by regulating apoptosis; however, challenges such as a lack of standardization, hinder their clinical application. This review examines the research progress on the roles of MSCs and MSC-EVs in this disease.