Yuan CX, Wang X, Liu Y, Xu TC, Yu Z, Xu B. Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress. World J Diabetes 2025; 16(2): 93130 [DOI: 10.4239/wjd.v16.i2.93130]
Corresponding Author of This Article
Bin Xu, PhD, Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. xubin@njucm.edu.cn
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Feb 15, 2025; 16(2): 93130 Published online Feb 15, 2025. doi: 10.4239/wjd.v16.i2.93130
Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress
Chong-Xi Yuan, Xuan Wang, Yun Liu, Tian-Cheng Xu, Zhi Yu, Bin Xu
Chong-Xi Yuan, Department of Traditional Chinese Medicine, Suzhou Xiangcheng People's Hospital, Suzhou 215100, Jiangsu Province, China
Chong-Xi Yuan, Xuan Wang, Yun Liu, Tian-Cheng Xu, Zhi Yu, Bin Xu, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Xuan Wang, College of Traditional Chinese Medicine, Jiangsu Vocational College of Medicine, Yancheng 224000, Jiangsu Province, China
Co-first authors: Chong-Xi Yuan and Xuan Wang.
Co-corresponding authors: Zhi Yu and Bin Xu.
Author contributions: Yuan CX and Wang X contributed equally to this study as co-first authors; Yu Z and Xu B contributed equally to this study as co-corresponding authors; Yuan CX conceived and designed the experiments; Yuan CX and Wang X performed the experiments, wrote the manuscript, and analyzed the data; Liu Y and Xu TC performed the experiments; Xu B and Yu Z provided guidance and funding support.
Supported by National Natural Science Foundation of China, No. 82074532, No. 82374577, No. 82305375, No. 82305376, and No. 82405567; and The Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals.
Conflict-of-interest statement: I certify that there is no actual or potential conflict of interest in relation to this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Xu, PhD, Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. xubin@njucm.edu.cn
Received: February 20, 2024 Revised: September 15, 2024 Accepted: October 31, 2024 Published online: February 15, 2025 Processing time: 313 Days and 23.1 Hours
Core Tip
Core Tip: Diabetic peripheral neuropathy (DPN) is thought to be linked to the vicious cycle of oxidative stress and mitochondrial dysfunction triggered by metabolic abnormalities. Electroacupuncture is commonly used as an adjuvant therapy for DPN in clinical practice, though its precise mechanism remains unclear. A rat model of DPN was established by combining a high-fat diet with streptozotocin injection. The final results suggest that the beneficial effects of electroacupuncture on DPN rats may be related to the regulation of the silent information regulator type 2 homolog-1/peroxisome proliferator-activated receptor-gamma coactivator-1α axis, which activates mitochondrial biogenesis and reduces oxidative stress and protects intact mitochondria.
