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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2025; 16(12): 113237
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.113237
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.113237
Serum C-reactive protein and C-reactive protein derived markers in diabetic microvascular complications
Burcin Meryem Atak Tel, Department of Internal Medicine, Bolu Abant Izzet Baysal University Hospital, Bolu 14030, Türkiye
Atiqa Khalid, Department of Endocrinology, Diabetes, and Metabolic Diseases, Buch International Hospital, Multan 59260, Punjab, Pakistan
Gulali Aktas, Department of Internal Medicine, Abant Izzet Baysal University, Bolu 14030, Türkiye
Author contributions: Atak Tel BM and Khalid A designed the work; Khalid A and Aktas G performed literature research; Atak Tel BM and Khalid A wrote the first draft; Atak Tel BM and Aktas G performed critical review of the manuscript. All authors approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gulali Aktas, Chief Physician, Professor, Department of Internal Medicine, Abant Izzet Baysal University, Golkoy, Bolu 14030, Türkiye. draliaktas@yahoo.com
Received: August 20, 2025
Revised: September 14, 2025
Accepted: November 12, 2025
Published online: December 15, 2025
Processing time: 117 Days and 19.4 Hours
Revised: September 14, 2025
Accepted: November 12, 2025
Published online: December 15, 2025
Processing time: 117 Days and 19.4 Hours
Core Tip
Core Tip: Type 2 diabetes mellitus (T2DM) is a chronic condition marked by high blood glucose, insulin resistance, and chronic inflammation. It is often accompanied by severe complications and systemic inflammation. Recent research highlighted C-reactive protein (CRP) and CRP derived markers such as high sensitivity-CRP, CRP-to-albumin ratio, and CRP-to-lymphocyte count ratio, as valuable tools for predicting the onset, progression, and complications of T2DM and diabetic microvascular complications. These markers are easily accessible through blood tests and serum biochemistry. They provide important data into inflammation and vascular changes linked to T2DM, including neuropathy, nephropathy, and retinopathy.