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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2025; 16(11): 111400
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.111400
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.111400
Crosstalk between oxidative stress and inflammatory pathways: Natural therapeutic approaches for diabetic wound healing
Yan-Ling Guo, Wen-Jing Niu, Hao-Ran Jiao, Yun-Ping Li, Jun Wang, Department of Wound and Vascular Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture Moxibustion, Tianjin 300381, China
Chuan Xu, Department of Pharmacy, Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Huzhou 313000, Zhejiang Province, China
Xin Zhou, Department of Science and Education, Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Huzhou 313000, Zhejiang Province, China
Co-corresponding authors: Xin Zhou and Jun Wang.
Author contributions: Zhou X and Wang J conceptualized and designed the review. Guo YL, Niu WJ, Jiao HR, Li YP, and Xu C contributed to data collection and manuscript editing; Guo YL drafted the initial version of the manuscript and prepared the first drafts of the figures and tables. All authors have read and approved the final version of the manuscript. As co-corresponding authors, Zhou X and Wang J made essential and complementary contributions to the completion of this review. Wang J provided overall academic guidance, supervised the writing process, and critically reviewed the references to ensure their accuracy and relevance. Zhou X contributed to topic selection, figure and table refinement, and was responsible for the final integration, revision, and submission of the manuscript. Their collaboration was essential for the successful completion and publication of this review article.
Supported by National Natural Science Foundation of China, No. 81973854; Scientific Research Programme Project of Hebei Provincial Administration of Traditional Chinese Medicine, No. T2025095; the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine ‘Tuoxin Project’ Fund Scientific Research Topics, No. 2023012; and Key Project of the Huzhou City Science and Technology Plan, No. 2023GZ83.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Wang, MD, Professor, Department of Wound and Vascular Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture Moxibustion, No. 88 Changling Road, Xiqing District, Tianjin 300381, China. tjzywangjun@126.com
Received: June 30, 2025
Revised: July 28, 2025
Accepted: September 26, 2025
Published online: November 15, 2025
Processing time: 138 Days and 21 Hours
Revised: July 28, 2025
Accepted: September 26, 2025
Published online: November 15, 2025
Processing time: 138 Days and 21 Hours
Core Tip
Core Tip: Oxidative stress and inflammation significantly impede wound healing in diabetes through a complex interactive mechanism. Natural therapeutic agents, including polyphenols, flavonoids, and terpenoids, have shown promise in mitigating oxidative damage and inflammatory responses and promoting angiogenesis, collagen deposition, and fibroblast function. This review highlights the intricate crosstalk between oxidative stress and inflammatory pathways in diabetic wound healing and underscores the potential of natural products as adjunctive therapies, emphasizing the need for further clinical validation to establish their efficacy and safety.