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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2025; 16(11): 109455
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.109455
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.109455
N7-methylguanosine-related gene decapping scavenger enzymes as a novel biomarker regulating epithelial cell function in diabetic foot ulcers
Fu-Gang Xiao, Zhou Yang, Shi-Yan Yu, Qin Li, Peng-Cheng Huang, Xiao-Gang Li, Jun-Lin Ran, Shun-Li Rui, Wu-Quan Deng, Department of Endocrinology and Metabolism, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, Chongqing 400014, China
Guang-Bin Huang, Department of Traumatology, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, Chongqing 400014, China
Wu-Quan Deng, School of Life Course and Population Health Science, King’s College London, London WC2R 2LS, United Kingdom
Co-first authors: Fu-Gang Xiao and Zhou Yang.
Co-corresponding authors: Shun-Li Rui and Wu-Quan Deng.
Author contributions: Xiao FG and Yang Z made equal contributions as co-first authors; Xiao FG, Yu SY, and Deng WQ contributed to writing original draft; Xiao FG, Yang Z, Li Q, Huang PC, and Huang GB contributed to data curation; Xiao FG, Yang Z, Yu SY, Huang PC, and Huang GB contributed to methodology, formal analysis, and software; Xiao FG, Yu SY, and Deng WQ contributed to visualization; Yang Z, Li Q, Huang PC, Huang GB, Rui SL, and Deng WQ contributed to resources; Yang Z, Li XG, Ran JL, Rui SL, and Deng WQ contributed to writing-review and editing; Li XG, Ran JL, and Rui SL contributed to supervision; Rui SL and Deng WQ contributed to validation and investigation, and made equal contributions as co-corresponding authors; Deng WQ contributed to project administration, funding acquisition, and conceptualization. All authors approved the final version to publish.
Supported by National Natural Science Foundation of China, No. 82370903; Noncommunicable Chronic Diseases-National Science and Technology Major Project, No. 2023ZD0509400 and No. 2023ZD0509402; 2023 Key Disciplines on Public Health Construction of Chongqing, the Natural Science Foundation of Chongqing Municipal Science and Technology Bureau, No. cstc2024ycjh-bgzxm0014; and Major Project of Science and Technology Research Program of Chongqing Education Commission of China, No. KJZD-M202400102.
Institutional review board statement: The study was reviewed and approved by the Fourth People’s Hospital of Chongqing Institutional Review Board, No. 2023-32.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Participants gave informed consent for data sharing. The data available from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wu-Quan Deng, MD, PhD, Chief Physician, Tenured Professor, Department of Endocrinology and Metabolism, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, No. 1 Jiankang Road, Chongqing 400014, China. wuquandeng@cqu.edu.cn
Received: May 12, 2025
Revised: July 8, 2025
Accepted: October 11, 2025
Published online: November 15, 2025
Processing time: 186 Days and 22.4 Hours
Revised: July 8, 2025
Accepted: October 11, 2025
Published online: November 15, 2025
Processing time: 186 Days and 22.4 Hours
Core Tip
Core Tip: This study identified decapping scavenger enzyme (DCPS) as a potential biomarker and therapeutic target for diabetic foot ulcers. It demonstrated that DCPS regulated m7G methylation, which affected cell cycle progression, proliferation, and migration of epithelial cells, which are crucial for wound healing. DCPS expression was significantly reduced in diabetic foot ulcer patients and diabetic mouse models, and its knockdown disrupted cell function, making it a promising target for improving healing in chronic nonhealing wounds.