Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2025; 16(10): 108714
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.108714
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.108714
Role of astrocytes in diabetic neuropathy: Review of their involvement in disease mechanisms
Khalilah Haris, Idris Long, Biomedicine Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
Co-first authors: Khalilah Haris and Idris Long.
Author contributions: Haris K wrote the manuscript; Long I conceived the study and contributed to the writing and review of the manuscript. Haris K and Long I contributed equally to this study as co-first authors.
Supported by the Fundamental Research Grant Scheme of the Ministry of Higher Education, Malaysia, No. FRGS/1/2024/SKK10/USM/02/8.
Conflict-of-interest statement: The author(s) declared no potential conflicts of interest concerning the research, authorship, and publication of this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Idris Long, Associate Professor, Biomedicine Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia. idriskk@usm.my
Received: April 22, 2025
Revised: July 4, 2025
Accepted: September 1, 2025
Published online: October 15, 2025
Processing time: 177 Days and 3.7 Hours
Revised: July 4, 2025
Accepted: September 1, 2025
Published online: October 15, 2025
Processing time: 177 Days and 3.7 Hours
Core Tip
Core Tip: This paper critically reviews the role of astrocytes in the mechanism of diabetic neuropathy (DN). We discuss the signaling pathways, protein kinases, receptors, and mediators that are involved in the pathophysiology of DN. We also explore research that focuses on astrocyte activation as a potential treatment for DN.