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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2025; 16(10): 108346
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.108346
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.108346
Potential roles of histone deacetylases in diabetic wound healing
Fang Zhang, Ling-Li Jiang, Kai-Yu Nie, Cheng-Liang Deng, Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Hong-Gang Ma, Bing Zhang, Ying Liu, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou 313000, Zhejiang Province, China
Co-first authors: Fang Zhang and Hong-Gang Ma.
Co-corresponding authors: Cheng-Liang Deng and Ying Liu.
Author contributions: Zhang F and Liu Y designed and conceptualized the paper; Zhang F and Ma HG wrote the paper; Jiang LL, Nie KY and Deng CL searched and analyzed the literature; Liu Y, Zhang B and Deng CL reviewed and edited the paper; All authors have read and approved the final manuscript.
Supported by the Guizhou Provincial Basic Research Program (Natural Science), No. ZK[2024]297.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Liu, MD, Postdoctoral Fellow, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, No. 1558 Third Ring North Road, Huzhou 313000, Zhejiang Province, China. 15950562208@163.com
Received: April 13, 2025
Revised: May 28, 2025
Accepted: August 26, 2025
Published online: October 15, 2025
Processing time: 187 Days and 1.1 Hours
Revised: May 28, 2025
Accepted: August 26, 2025
Published online: October 15, 2025
Processing time: 187 Days and 1.1 Hours
Core Tip
Core Tip: Repeated failure of diabetic wounds to heal is a critical global health issue that significantly contributes to the incidence of non-traumatic amputations. However, the mechanisms underlying the impaired healing of diabetic wounds are intricate and incompletely elucidated. In this review, we analyze the pivotal roles of histone deacetylases in the critical events in diabetic wound healing.