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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2022; 13(8): 622-642
Published online Aug 15, 2022. doi: 10.4239/wjd.v13.i8.622
Published online Aug 15, 2022. doi: 10.4239/wjd.v13.i8.622
In vivo evaluation and mechanism prediction of anti-diabetic foot ulcer based on component analysis of Ruyi Jinhuang powder
Xiu-Yan Li, Yi-Cheng Jiao, Hang Chi, Ting-Ting Xiong, Wen-Jing Zhang, Mi-Nan Li, Yan-Hong Wang, Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Xiu-Yan Li, College of Pharmacy, Harbin Medical University, Harbin 150040, Heilongjiang Province, China
Xiao-Tong Zhang, Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, College of Pharmacy, Harbin 150040, Heilongjiang Province, China
Author contributions: Li XY, Zhang XT, Jiao YC, Chi H, Xiong TT and Zhang WJ, Li MN performed the experiments and acquired and analyzed the data; Li XY, Zhang XT and Wang YH wrote the manuscript; all authors approved the final version of the article.
Supported by National Natural Science Foundation of China , No. 82074025 ; Scientific Research Project of Heilongjiang Health Committee , No. 2020-293 ; and Scientific and Technological Innovation Project for College Students of Heilongjiang University of Chinese Medicine , No. 2021-13 .
Institutional review board statement: This study does not involve human.
Institutional animal care and use committee statement: This study was approved by Ethics Committee of Heilongjiang University of Chinese Medicine, Harbin, China.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Hong Wang, MD, Teacher, Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Xiangfang District, Harbin 150040, Heilongjiang Province, China. 799378826@qq.com
Received: May 6, 2022
Peer-review started: May 6, 2022
First decision: May 30, 2022
Revised: June 10, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: August 15, 2022
Processing time: 98 Days and 0.9 Hours
Peer-review started: May 6, 2022
First decision: May 30, 2022
Revised: June 10, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: August 15, 2022
Processing time: 98 Days and 0.9 Hours
Core Tip
Core Tip: Although some studies have suggested that Ruyi Jinhuang powder (RHP) has a therapeutic effect on diabetic foot ulcers (DFUs), few have used component analysis, investigated the mechanism of action, and utilized wound-healing experiments. The components of RHP were used to predict the mechanism of action, and wound healing was observed by establishing a DFU rat model to further prove the therapeutic effect of RHP on DFU to finally determine a possible mechanism of action.