Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.1103
Peer-review started: March 28, 2023
First decision: April 10, 2023
Revised: April 23, 2023
Accepted: May 23, 2023
Article in press: May 23, 2023
Published online: July 15, 2023
Processing time: 106 Days and 22.5 Hours
Diabetic retinopathy (DR) is a common complication of diabetes, which can eventually lead to blindness and seriously affect the quality of life of diabetic patients. Therefore, identification of the risk factors of DR is significant for early intervention.
This study explored the risk factors for DR and their predictive effect on retinopathy.
This study aimed to investigate the correlation between glycated hemoglobin A1c (HbA1c), urinary microalbumin (U-mALB), urinary creatinine (U-CR), mALB/U-CR ratio, β2 microglobulin (β2MG), retinol binding protein (RBP) and DR.
Based on real population data, a retrospective study was carried out.
Duration of disease, HbA1c, mALB, β2MG, RBP, mALB/U-CR and U-CR were found to be risk factors for the development of DR. The area under the curve of the combined indices (HbA1c + mALB + mALB/U-CR + U-CR + β2MG + RBP) was 0.958.
The combination of HbA1c, mALB, mALB/U-CR, U-CR, β2MG and RBP has predictive value for proliferative DR.
Large multicenter studies are needed to further verify these results.