Song JJ, Han XF, Chen JF, Liu KM. Correlation between glycated hemoglobin A1c, urinary microalbumin, urinary creatinine, β2 microglobulin, retinol binding protein and diabetic retinopathy. World J Diabetes 2023; 14(7): 1103-1111 [PMID: 37547593 DOI: 10.4239/wjd.v14.i7.1103]
Corresponding Author of This Article
Jia-Jia Song, MM, Associate Chief Physician, Department of Endocrinology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, No. 246 Heping Road, Yaohai District, Hefei 230011, Anhui Province, China. sjj1832613@126.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Retrospective Study
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Song JJ, Han XF, Chen JF, Liu KM. Correlation between glycated hemoglobin A1c, urinary microalbumin, urinary creatinine, β2 microglobulin, retinol binding protein and diabetic retinopathy. World J Diabetes 2023; 14(7): 1103-1111 [PMID: 37547593 DOI: 10.4239/wjd.v14.i7.1103]
World J Diabetes. Jul 15, 2023; 14(7): 1103-1111 Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.1103
Correlation between glycated hemoglobin A1c, urinary microalbumin, urinary creatinine, β2 microglobulin, retinol binding protein and diabetic retinopathy
Jia-Jia Song, Xiao-Fang Han, Jian-Feng Chen, Ke-Mei Liu
Jia-Jia Song, Xiao-Fang Han, Jian-Feng Chen, Ke-Mei Liu, Department of Endocrinology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei 230011, Anhui Province, China
Author contributions: Song JJ contributed to the conceptualization, funding acquisition, resources, supervision, methodology, software, investigation, formal analysis, writing - original draft, visualization, writing, review and editing of the manuscript; Han XF contributed to the data curation, writing and original draft of the manuscript; Chen JF contributed to the visualization, investigation, resources, supervision of the study; Liu KM contributed to the software and validation of data.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Second People’s Hospital of Hefei (No. 2023014).
Informed consent statement: This study only used anonymous data in the system, and did not require informed consent according to institutional policy.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: According to institutional policy, the third party has no access to obtain the data.
Corresponding author: Jia-Jia Song, MM, Associate Chief Physician, Department of Endocrinology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, No. 246 Heping Road, Yaohai District, Hefei 230011, Anhui Province, China. sjj1832613@126.com
Received: March 28, 2023 Peer-review started: March 28, 2023 First decision: April 10, 2023 Revised: April 23, 2023 Accepted: May 23, 2023 Article in press: May 23, 2023 Published online: July 15, 2023 Processing time: 106 Days and 22.5 Hours
ARTICLE HIGHLIGHTS
Research background
Diabetic retinopathy (DR) is a common complication of diabetes, which can eventually lead to blindness and seriously affect the quality of life of diabetic patients. Therefore, identification of the risk factors of DR is significant for early intervention.
Research motivation
This study explored the risk factors for DR and their predictive effect on retinopathy.
Research objectives
This study aimed to investigate the correlation between glycated hemoglobin A1c (HbA1c), urinary microalbumin (U-mALB), urinary creatinine (U-CR), mALB/U-CR ratio, β2 microglobulin (β2MG), retinol binding protein (RBP) and DR.
Research methods
Based on real population data, a retrospective study was carried out.
Research results
Duration of disease, HbA1c, mALB, β2MG, RBP, mALB/U-CR and U-CR were found to be risk factors for the development of DR. The area under the curve of the combined indices (HbA1c + mALB + mALB/U-CR + U-CR + β2MG + RBP) was 0.958.
Research conclusions
The combination of HbA1c, mALB, mALB/U-CR, U-CR, β2MG and RBP has predictive value for proliferative DR.
Research perspectives
Large multicenter studies are needed to further verify these results.
