Luo LY, Liu ZX, Yang TS, Liang W, Luo XL. Right ventricular dysfunction in type 1 diabetic cardiomyopathy: An overlooked component? World J Diabetes 2026; 17(1): 114618 [DOI: 10.4239/wjd.v17.i1.114618]
Corresponding Author of This Article
Xue-Lian Luo, MD, PhD, Department of Oncology, The Third Affiliated Hospital of Chongqing Medical University, Huixing Street, Yubei District, Chongqing 401120, China. 806850653@qq.com
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Cardiac & Cardiovascular Systems
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Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 15, 2026 (publication date) through Jan 14, 2026
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Publication Name
World Journal of Diabetes
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1948-9358
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Luo LY, Liu ZX, Yang TS, Liang W, Luo XL. Right ventricular dysfunction in type 1 diabetic cardiomyopathy: An overlooked component? World J Diabetes 2026; 17(1): 114618 [DOI: 10.4239/wjd.v17.i1.114618]
World J Diabetes. Jan 15, 2026; 17(1): 114618 Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.114618
Right ventricular dysfunction in type 1 diabetic cardiomyopathy: An overlooked component?
Ling-Yun Luo, Zi-Xuan Liu, Tian-Shu Yang, Wei Liang, Xue-Lian Luo
Ling-Yun Luo, Zi-Xuan Liu, Tian-Shu Yang, Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Wei Liang, Xue-Lian Luo, Department of Oncology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China
Co-first authors: Ling-Yun Luo and Zi-Xuan Liu.
Co-corresponding authors: Wei Liang and Xue-Lian Luo.
Author contributions: Luo XL and Liang W contribute to the conception and design of the work as co-corresponding authors; Luo LY and Liu ZX have drafted the work as co-first authors; Yang TS and Luo XL substantively revised it. All authors have approved the submitted version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Lian Luo, MD, PhD, Department of Oncology, The Third Affiliated Hospital of Chongqing Medical University, Huixing Street, Yubei District, Chongqing 401120, China. 806850653@qq.com
Received: September 24, 2025 Revised: November 8, 2025 Accepted: December 3, 2025 Published online: January 15, 2026 Processing time: 112 Days and 10.7 Hours
Abstract
While left ventricular (LV) impairment in diabetic cardiomyopathy is well recognized, the contribution of right ventricular (RV) dysfunction has received far less attention. In their longitudinal investigation, Yu et al systematically examined RV and LV performance in a type 1 diabetic mouse model and demonstrated that RV diastolic dysfunction develops later than LV abnormalities, coinciding with structural remodeling marked by fibrosis, hypertrophy, and mild pulmonary hypertension. These observations underscore the progressive yet distinct trajectory of RV pathology in diabetes and point to the importance of incorporating RV assessment into the overall cardiac evaluation of diabetic patients. This letter explores the broader significance of these findings and highlights the urgent need for studies focused on RV-specific mechanisms and targeted therapies aimed at preventing or attenuating biventricular injury in diabetic cardiomyopathy.
Core Tip: In type 1 diabetic cardiomyopathy, right ventricular (RV) function is a key determinant of patient prognosis and must not be neglected. RV performance should be incorporated into the inclusion criteria and endpoint selection of clinical trials. There is a critical need for more robust surrogate markers to evaluate RV-pulmonary arterial coupling. Additionally, the development of therapies that directly improve RV systolic and diastolic function is urgently required.
