Liao L, Luo A, Zhang LH, Pan YT, Liu YQ. Commentary on α-1-microglobulin as a predictor of diabetic complications. World J Diabetes 2026; 17(1): 114210 [DOI: 10.4239/wjd.v17.i1.114210]
Corresponding Author of This Article
Li Liao, PhD, School of Nursing, University of South China, No. 28 West Changsheng Road, Hengyang 421001, Hunan Province, China. 254251558@qq.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 15, 2026 (publication date) through Jan 14, 2026
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Publication Name
World Journal of Diabetes
ISSN
1948-9358
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Liao L, Luo A, Zhang LH, Pan YT, Liu YQ. Commentary on α-1-microglobulin as a predictor of diabetic complications. World J Diabetes 2026; 17(1): 114210 [DOI: 10.4239/wjd.v17.i1.114210]
World J Diabetes. Jan 15, 2026; 17(1): 114210 Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.114210
Commentary on α-1-microglobulin as a predictor of diabetic complications
Li Liao, An Luo, Long-Han Zhang, Yi-Ting Pan, Ya-Qing Liu
Li Liao, An Luo, Long-Han Zhang, Yi-Ting Pan, Ya-Qing Liu, School of Nursing, University of South China, Hengyang 421001, Hunan Province, China
Author contributions: Liao L and Luo A conceived the study and drafted the manuscript; Zhang LH, Pan YT and Liu YQ contributed to critical review, editing, and intellectual revision of the content; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Liao, PhD, School of Nursing, University of South China, No. 28 West Changsheng Road, Hengyang 421001, Hunan Province, China. 254251558@qq.com
Received: September 15, 2025 Revised: October 25, 2025 Accepted: November 19, 2025 Published online: January 15, 2026 Processing time: 122 Days and 18.1 Hours
Abstract
This letter comments on the study by Ge et al. Serum α1-microglobulin (α1-MG) was reported to be associated with diabetic nephropathy, retinopathy, peripheral neuropathy, and left ventricular hypertrophy. The letter further highlights the need for multicenter validation and evaluation of clinical applicability to clarify the role of α1-MG in diabetes management.
Core Tip: This letter comments on the recent study regarding serum α1-microglobulin (α1-MG) as a predictor of multiple complications in type 2 diabetes mellitus. The letter underscores the importance of α1-MG as a potential biomarker linking renal, retinal, neural, and cardiac complications, and highlights the need for multi-center validation and cost-effectiveness evaluation before clinical adoption.
