Zhao Y, Shen QQ. Acellular fish skin grafts in diabetic foot ulcer care: Advances and clinical insights. World J Diabetes 2025; 16(1): 100597 [DOI: 10.4239/wjd.v16.i1.100597]
Corresponding Author of This Article
Quan-Quan Shen, Associate Professor, MD, Department of Nephrology, Zhejiang Provincial People’s Hospital Bijie Hospital, No. 112 Guanghui Road, Bijie 551700, Guizhou Province, China. spring198457@sina.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jan 15, 2025; 16(1): 100597 Published online Jan 15, 2025. doi: 10.4239/wjd.v16.i1.100597
Acellular fish skin grafts in diabetic foot ulcer care: Advances and clinical insights
Yu Zhao, Quan-Quan Shen
Yu Zhao, Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China
Quan-Quan Shen, Department of Nephrology, Zhejiang Provincial People’s Hospital Bijie Hospital, Bijie 551700, Guizhou Province, China
Quan-Quan Shen, Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, China
Author contributions: Zhao Y drafted the manuscript; Shen QQ designed and revised the manuscript; both authors have read and approved the final manuscript.
Supported by the Zhejiang Medical Technology Project, No. 2022RC009 and No. 2024KY645.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Quan-Quan Shen, Associate Professor, MD, Department of Nephrology, Zhejiang Provincial People’s Hospital Bijie Hospital, No. 112 Guanghui Road, Bijie 551700, Guizhou Province, China. spring198457@sina.com
Received: August 21, 2024 Revised: October 23, 2024 Accepted: November 13, 2024 Published online: January 15, 2025 Processing time: 101 Days and 13.3 Hours
Abstract
Diabetic foot ulcers (DFUs) represents a significant public health issue, with a rising global prevalence and severe potential complications including amputation. Traditional treatments often fall short due to various limitations such as high recurrence rates and extensive resource utilization. This editorial explores the innovative use of acellular fish skin grafts as a transformative approach in DFU management. Recent studies and a detailed case report highlight the efficacy of acellular fish skin grafts in accelerating wound closure, reducing dressing changes, and enhancing patient outcomes with a lower socio-economic burden. Despite their promise, challenges such as limited availability, patient acceptance, and the need for further research persist. Addressing these through more extensive randomized controlled trials and fostering a multidisciplinary treatment approach may optimize DFU care and reduce the global health burden associated with these complex wounds.
Core Tip: This editorial explores the innovative use of acellular fish skin grafts (AFSGs) in the management of diabetic foot ulcers (DFUs). It introduces AFSGs as a bioengineered alternative that mimics the natural extracellular matrix, enhancing healing by promoting cell migration and tissue integration. The unique properties of AFSGs include reducing dressing changes, enhancing healing rates, and minimizing patient discomfort. This article calls for further randomized controlled trials to validate the effectiveness of AFSGs in diverse DFU cases and stresses the importance of a multidisciplinary approach in DFU management.
