Demirel S. Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes. World J Diabetes 2024; 15(6): 1122-1141 [PMID: 38983824 DOI: 10.4239/wjd.v15.i6.1122]
Corresponding Author of This Article
Sadettin Demirel, BSc, MSc, PhD, Associate Professor, Medicine School, Physiology Department, Bursa Uludag University, Nilufer, Bursa 16059, Türkiye. sdemirel@uludag.edu.tr
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jun 15, 2024; 15(6): 1122-1141 Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1122
Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes
Sadettin Demirel
Sadettin Demirel, Medicine School, Physiology Department, Bursa Uludag University, Bursa 16059, Türkiye
Author contributions: Demirel S designed the project and wrote the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sadettin Demirel, BSc, MSc, PhD, Associate Professor, Medicine School, Physiology Department, Bursa Uludag University, Nilufer, Bursa 16059, Türkiye. sdemirel@uludag.edu.tr
Received: December 30, 2023 Revised: March 7, 2024 Accepted: May 6, 2024 Published online: June 15, 2024 Processing time: 163 Days and 21.6 Hours
Abstract
Endothelial function plays a pivotal role in cardiovascular health, and dysfunction in this context diminishes vasorelaxation concomitant with endothelial activity. The nitric oxide-cyclic guanosine monophosphate pathway, prostacyclin-cyclic adenosine monophosphate pathway, inhibition of phosphodiesterase, and the opening of potassium channels, coupled with the reduction of calcium levels in the cell, constitute critical mechanisms governing vasorelaxation. Cardiovascular disease stands as a significant contributor to morbidity and mortality among individuals with diabetes, with adults afflicted by diabetes exhibiting a heightened cardiovascular risk compared to their non-diabetic counterparts. A plethora of medicinal plants, characterized by potent pharmacological effects and minimal side effects, holds promise in addressing these concerns. In this review, we delineate various medicinal plants and their respective biochemical constituents, showcasing concurrent vasorelaxant and anti-diabetic activities.
Core Tip: To the best of our knowledge, this study is pioneering, offering a unique perspective that addresses both vasorelaxation and diabetes concerning medicinal plants. The comprehensive collection of medicinal plant references presented in this study is anticipated to serve as a valuable resource, inspiring and guiding future investigations into cardiovascular diseases and diabetes.
