Zhang HM, Yang ML, Xi JZ, Yang GY, Wu QN. Mesenchymal stem cells-based drug delivery systems for diabetic foot ulcer: A review. World J Diabetes 2023; 14(11): 1585-1602 [PMID: 38077806 DOI: 10.4239/wjd.v14.i11.1585]
Corresponding Author of This Article
Qi-Nan Wu, Doctor, MD, Director, Professor, Department of Endocrinology, Dazu Hospital of Chongqing Medical University, The People’s Hospital of Dazu, No. 1073 Second Ring South Road, Hongxing Community, Tangxiang Street, Dazu District, Chongqing 406230, China. wqn11@126.com
Research Domain of This Article
Methodology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hong-Min Zhang, Department of Endocrinology, People’s Hospital of Chongqing Liangjiang New Area, Chongqing 400030, China
Meng-Liu Yang, Gang-Yi Yang, Department of Endocrinology, The Second Affiliated Hospital of The Chongqing Medical University, Chongqing 400030, China
Jia-Zhuang Xi, Qi-Nan Wu, Department of Endocrinology, Dazu Hospital of Chongqing Medical University, The People’s Hospital of Dazu, Chongqing 406230, China
Author contributions: Zhang HM, Yang ML, Xi JZ, Yang GY and Wu QN contributed to writing the manuscript and participated in helpful discussions; Wu QN is the guarantor of this work.
Supported byScience and Health Joint Medical Research Project of Chongqing, No. 2022MSXM133; Natural Science Foundation of Chongqing, No. CSTB2022NSCQ-MSX1522, No. CSTB2023NSCQ-MSX0246, and No. CSTB2022NSCQ-MSX1271; The First Batch of Key Disciplines on Public Health in Chongqing and Science; and Health Joint Project of Dazu District Science and Technology Bureau, No. DZKJ,2022CCC1001.
Conflict-of-interest statement: The authors have no conflicts of interest and all agreed to publish the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Nan Wu, Doctor, MD, Director, Professor, Department of Endocrinology, Dazu Hospital of Chongqing Medical University, The People’s Hospital of Dazu, No. 1073 Second Ring South Road, Hongxing Community, Tangxiang Street, Dazu District, Chongqing 406230, China. wqn11@126.com
Received: July 1, 2023 Peer-review started: July 1, 2023 First decision: July 6, 2023 Revised: July 16, 2023 Accepted: September 11, 2023 Article in press: September 11, 2023 Published online: November 15, 2023 Processing time: 135 Days and 15.9 Hours
Abstract
The complication of diabetes, which is known as diabetic foot ulcer (DFU), is a significant concern due to its association with high rates of disability and mortality. It not only severely affects patients’ quality of life, but also imposes a substantial burden on the healthcare system. In spite of efforts made in clinical practice, treating DFU remains a challenging task. While mesenchymal stem cell (MSC) therapy has been extensively studied in treating DFU, the current efficacy of DFU healing using this method is still inadequate. However, in recent years, several MSCs-based drug delivery systems have emerged, which have shown to increase the efficacy of MSC therapy, especially in treating DFU. This review summarized the application of diverse MSCs-based drug delivery systems in treating DFU and suggested potential prospects for the future research.
Core Tip: Diabetic foot ulcer (DFU) is a significant concern due to its association with high rates of disability and mortality. Mesenchymal stem cell (MSC) therapy has been extensively studied in treating DFU, the current efficacy of DFU healing using this method is still inadequate. However, in recent years, several MSCs-based drug delivery systems have emerged, which have shown to increase the efficacy of MSC therapy, especially in treating DFU.
