Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2023; 14(11): 1585-1602
Published online Nov 15, 2023. doi: 10.4239/wjd.v14.i11.1585
Mesenchymal stem cells-based drug delivery systems for diabetic foot ulcer: A review
Hong-Min Zhang, Meng-Liu Yang, Jia-Zhuang Xi, Gang-Yi Yang, Qi-Nan Wu
Hong-Min Zhang, Department of Endocrinology, People’s Hospital of Chongqing Liangjiang New Area, Chongqing 400030, China
Meng-Liu Yang, Gang-Yi Yang, Department of Endocrinology, The Second Affiliated Hospital of The Chongqing Medical University, Chongqing 400030, China
Jia-Zhuang Xi, Qi-Nan Wu, Department of Endocrinology, Dazu Hospital of Chongqing Medical University, The People’s Hospital of Dazu, Chongqing 406230, China
Author contributions: Zhang HM, Yang ML, Xi JZ, Yang GY and Wu QN contributed to writing the manuscript and participated in helpful discussions; Wu QN is the guarantor of this work.
Supported by Science and Health Joint Medical Research Project of Chongqing, No. 2022MSXM133; Natural Science Foundation of Chongqing, No. CSTB2022NSCQ-MSX1522, No. CSTB2023NSCQ-MSX0246, and No. CSTB2022NSCQ-MSX1271; The First Batch of Key Disciplines on Public Health in Chongqing and Science; and Health Joint Project of Dazu District Science and Technology Bureau, No. DZKJ,2022CCC1001.
Conflict-of-interest statement: The authors have no conflicts of interest and all agreed to publish the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Nan Wu, Doctor, MD, Director, Professor, Department of Endocrinology, Dazu Hospital of Chongqing Medical University, The People’s Hospital of Dazu, No. 1073 Second Ring South Road, Hongxing Community, Tangxiang Street, Dazu District, Chongqing 406230, China. wqn11@126.com
Received: July 1, 2023
Peer-review started: July 1, 2023
First decision: July 6, 2023
Revised: July 16, 2023
Accepted: September 11, 2023
Article in press: September 11, 2023
Published online: November 15, 2023
Processing time: 135 Days and 15.9 Hours
Core Tip

Core Tip: Diabetic foot ulcer (DFU) is a significant concern due to its association with high rates of disability and mortality. Mesenchymal stem cell (MSC) therapy has been extensively studied in treating DFU, the current efficacy of DFU healing using this method is still inadequate. However, in recent years, several MSCs-based drug delivery systems have emerged, which have shown to increase the efficacy of MSC therapy, especially in treating DFU.