Copyright: ©Author(s) 2026.
World J Gastrointest Oncol. May 15, 2026; 18(5): 116568
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116568
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116568
Table 1 Criteria for scoring of colonic damage
| Score | Criteria |
| 0 | No damage |
| 1 | Focal hyperemia without ulceration |
| 2 | Ulceration without hypertrophy of the intestinal wall |
| 3 | Ulceration with inflammation spot |
| 4 | Two or more sites of ulceration or inflammation |
| 5 | Large areas of inflammation and ulceration extending more than 1 cm |
| 6 | Large areas of tissue damage with an extension greater than 2 cm added 1 point for each additional 1 cm of extension |
Table 2 Affinity energy of receptor/Ligand complexes
| Receptors | Phenolic compounds | ||
| Gallic acid (kcal/mol) | Chlorogenic acid (kcal/mol) | p-hydroxybenzoic acid (kcal/mol) | |
| SPHK1 (PDB 3VZB) | -6.1 | -8.6 | -5.9 |
| S1PR1 (PDB 7TD3) | -5.9 | -8.7/-8.4 | -5.7 |
| IDO1 (PDB 5EK3) | -7.1 | -8.7 | -6.8 |
| COX-2 (PDB 5F1A) | -6.3 | -8.8 | -6.0 |
- Citation: Da Silva PB, Lopes-Bute L, Fischer J, Parcianello AP, Pires-Duarte R, Luiz RM, Brandalize APC, Melo FF, Wendel CF, Teixeira KN, Zarpelon-Schutz AC. Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities. World J Gastrointest Oncol 2026; 18(5): 116568
- URL: https://www.wjgnet.com/1948-5204/full/v18/i5/116568.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.116568