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World J Gastrointest Oncol. May 15, 2026; 18(5): 116568
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116568
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116568
Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities
Paola B Da Silva, Laís Lopes-Bute, Janaína Fischer, Ana P Parcianello, Cinthia F Wendel, Campus Toledo, Federal University of Parana, Toledo 85919-899, Parana, Brazil
Renata Pires-Duarte, Postgraduate Program of Biotechnology, Federal University of Parana-Palotina Sector, Palotina 85950-000, Paraná, Brazil
Rafael M Luiz, Campus Toledo, Federal University of Parana and Postgraduate on Biochemistry and Molecular Biology, Federal University of Parana-Palotina Sector, Palotina 85950-000, Paraná, Brazil
Ana P C Brandalize, Ana C Zarpelon-Schutz, Postgraduate on Biochemistry and Molecular Biology, Postgraduate Program of Biotechnology and Campus Toledo, Federal University of Parana, Toledo 85919-899, Parana, Brazil
Fabrício F Melo, Multidisciplinary Institute of Health, Federal University of Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
Kádima N Teixeira, Postgraduate on Biochemistry and Molecular Biology and Campus Toledo, Federal University of Parana, Toledo 85919-899, Parana, Brazil.
Author contributions: Da Silva PB, Lopes-Bute L, Fischer J, Parcianello AP, and Pires-Duarte R were involved in conducting the experiments and drafting the original manuscript; Luiz RM and Wendel CF contributed to project administration and data verification; Brandalize APC and Melo FF performed data verification; Teixeira KN was responsible for reviewing and editing the manuscript, as well as conducting the in silico analysis Zarpelon-Schutz AC was responsible for project administration, supervision, and formal analysis; all authors have read and approved the final version of the manuscript.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals (Ethics Committee for Animal Use of the Setor de Ciências Biológicas at the Universidade Federal do Paraná, Brazil, No. 1531/2023).
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Corresponding author: Ana C Zarpelon-Schutz, PhD, Postgraduate on Biochemistry and Molecular Biology, Postgraduate Program of Biotechnology and Campus Toledo, Federal University of Parana, Max Planck 3796, Toledo 85919-899, Paraná, Brazil.
Received: November 17, 2025
Revised: December 12, 2025
Accepted: February 6, 2026
Published online: May 15, 2026
Processing time: 181 Days and 15.4 Hours
Revised: December 12, 2025
Accepted: February 6, 2026
Published online: May 15, 2026
Processing time: 181 Days and 15.4 Hours
Core Tip
Core Tip: The hydroalcoholic extract of Butia capitata showed antinociceptive activity in mice, in models of pain and/or hyperalgesia caused by acetic acid, formalin, and carrageenan, with an emphasis on reducing the histological damage and the pain symptoms caused by acetic acid-induced acute colitis. The in silico results indicate the potential of phenolic compounds of the extract to inhibit cellular pathways and receptors involved in inflammatory processes, as well as reduce the activation of pathways that promote genetic damage and tumorigenesis.