Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis

doi:10.4251/wjgo.v18.i4.117815

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 4

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (83)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-7) series, Tables (1-1) series.

Item

Count

PDF

HTML

Figures (1-7)

Tables (1-1)

Sum=37

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=36

Apr 15, 2026 (publication date) through Apr 11, 2026

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Apr 15, 2026; 18(4): 117815
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.117815

Table 1 Primer sequences

Gene name	Sequence	Size (bp)
HIF-1α	Forward: ACCGTGCCCCTACTATGTCG	197
HIF-1α	Reverse: GCCTTGTATGGGAGCATTAACTT	197
VEGF	Forward: GCACTGGACCCTGGCTTTACT	102
VEGF	Reverse: AACTTCACCACTTCATGGGCTTT	102
BNIP3	Forward: CTTCAGCAATGGGAATGGGAG	160
BNIP3	Reverse: GGTATCTTGTGGTGTCTGGGAGC	160
Beclin1	Forward: AGGAGTTGCCGTTGTACTGTTCT	178
Beclin1	Reverse: GTGTCTTCAATCTTGCCTTTCTCC	178
LC3	Forward: TTGGTCAAGATCATCCGGCG	175
LC3	Reverse: AGCCGAAGGTTTCTTGGGAG	175
P62	Forward: GCTATTACAGCCAGAGTCAAGGG	105
P62	Reverse: TGGTCCCATTCCAGTCATCTT	105
COX4	Forward: CATCTTATGTTGATCGGCGTG	238
COX4	Reverse: GCAGTGAAGCCGATGAAGAACA	238
HK2	Forward: CCCATTTTGCCAAGCGTCTC	137
HK2	Reverse: TTGGTCAGCCAGACGGTAAG	137
LDHA	Forward: ATGAGCTTGCCCTTGTTGATGT	214
LDHA	Reverse: AAGATGTTCACGTTTCGCTGG	214
β-actin	Forward: TGCTATGTTGCCCTAGACTTCG	240
β-actin	Reverse: GTTGGCATAGAGGTCTTTACGG	240

β-actin was used as the internal control. BNIP3: BCL2/adenovirus E1B 19 kDa interacting protein 3; COX4: Cytochrome C oxidase subunit 4; HIF-1α: Hypoxia-inducible factor 1-alpha; HK2: Hexokinase 2; LC3: Light chain 3; LDHA: Lactate dehydrogenase A; P62: Sequestosome 1; VEGF: Vascular endothelial growth factor.

Full Size Table

Citation: Zhang XF, Lv GH, An SJ, Yang XR, Guo WZ, Yu CY, Zhu CH. Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis. World J Gastrointest Oncol 2026; 18(4): 117815
URL: https://www.wjgnet.com/1948-5204/full/v18/i4/117815.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i4.117815