Clinical and endoscopic characteristics of early gastric signet ring cell carcinoma based on Helicobacter pylori infection status

Table 1 Baseline and clinical characteristics of patients with early gastric signet ring cell carcinoma based on Helicobacter pylori infection status, n (%)

Variables	Overall	H. pylori-positive	H. pylori-eradicated	H. pylori-uninfected	P value
n = 29	12 (41.4)	7 (24.1)	10 (34.5)
Age, years, mean ± SD	47.55 ± 12.19	45.25 ± 10.26	54.14 ± 8.65	45.7 ± 15.75	0.347
Sex					0.542
Male	7 (24.1)	4 (33.3)	2 (28.6)	1 (10.0)
Female	22 (75.9)	8 (66.7)	5 (71.4)	9 (90.0)
Symptoms					0.398
Abdominal pain	9 (31.0)	4 (33.3)	1 (14.3)	4 (40.0)
Distension	3 (10.3)	2 (16.7)	0	1 (10.0)
Diarrhea/constipation	2 (7.9)	2 (16.7)	0	0
Routine screening	15 (51.7)	4 (33.3)	6 (85.7)	5 (50.0)
Management					0.545
ESD	19 (65.5)	7 (58.3)	6 (85.7)	6 (60.0)
Surgery	10 (34.5)	5 (41.7)	1 (14.3)	4 (40.0)
En bloc resection	29 (100.0)	12 (100.0)	7 (100.0)	10 (100.0)
Complication					0.25
Bleeding	3 (10.3)	3 (25.0)	0	0
Perforation	0	0	0	0
Infection	1 (3.4)	0	0	1 (10.0)
Anastomotic leakage	0	0	0	0
Recurrence	0	0	0	0

H. pylori: Helicobacter pylori; ESD: Endoscopic submucosal dissection.

Table 2 Endoscopic characteristics of patients with early gastric signet ring cell carcinoma based on Helicobacter pylori infection status, n (%)

Variables	Overall	H. pylori-positive	H. pylori-eradicated	H. pylori-uninfected	P value
n	29	12 (41.4)	7 (24.1)	10 (34.5)
Tumor size/mm (mean ± SD)	12.69 ± 5.04	13.2 ± 5.41	11.58 ± 4.57	13.47 ± 5.51	0.72
Tumor location					0.235
Gastric body	24 (82.8)	8 (66.7)	7 (100.0)	9 (90.0)
Upper third	7 (29.2)	3 (37.5)	3 (42.9)	1 (11.1)
Middle third	0	0	0	0
Lower third	17 (70.8)	5 (62.5)	4 (57.1)	8 (88.9)
Antrum	5 (17.2)	4 (33.3)	0	1 (10.0)
Morphology					0.101
0-IIb	13 (44.8)	3 (25.0)	2 (28.6)	8 (80.0)
0-IIc	10 (34.5)	6 (50.0)	3 (42.9)	1 (10.0)
0-IIa + IIc/0-IIc + IIa	6 (20.7)	3 (25.0)	2 (28.6)	1 (10.0)
Surface color					0.002
Whitish discoloration	15 (51.7)	2 (16.7)	4 (57.1)	9 (90.0)
Reddish roughness/spontaneous bleeding	14 (48.3)	10 (83.3)	3 (42.9)	1 (10.0)
VS classification					0.999
DL	29 (100.0)	12 (100.0)	7 (100.0)	10 (100.0)
Irregular MVP	26 (89.7)	10 (83.3)	7 (100.0)	9 (90.0)
Irregular MSP	26 (89.7)	9 (75.0)	7 (100.0)	10 (100.0)
Enlarged/absent IP	25 (86.2)	9 (75.0)	7 (100.0)	9 (90.0)

H. pylori: Helicobacter pylori; VS: Vessel plus surface; DL: Demarcation line; MVP: Microvascular pattern; MSP: Microsurface pattern; IP: Intervening part.