Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer

Table 1 Relationship between the expression of leukocyte immunoglobulin-like receptor B2, angiopoietin-like protein 2, and human leukocyte antigen-G in gastric cancer tissues and clinicopathological characteristics, n (%)

Characteristics	LILRB2		ANGPTL2		HLA-G
	High	Low	High	Low	High	Low
Age (years)
≤ 60	18 (62.1)	6 (35.3)	14 (53.8)	10 (50.0)	16 (47.1)	8 (66.7)
> 60	11 (37.9)	11 (64.7)	12 (46.2)	10 (50.0)	18 (52.9)	4 (33.3)
Gender
Male	20 (69.0)	13 (76.5)	18 (69.2)	15 (75.0)	22 (64.7)	11 (91.7)
Female	9 (31.0)	4 (23.5)	8 (30.8)	5 (25.0)	12 (35.3)	1 (8.3)
TNM stage
I/II	16 (55.2)	9 (52.9)	8 (30.8)	17 (85.0)a	17 (50.0)	8 (66.7)
III	13 (44.8)	8 (47.1)	18 (69.2)	3 (15.0)	17 (50.0)	4 (33.3)
Tumor depth
T1/2	11 (37.9)	7 (41.2)	7 (26.9)	11 (55.0)	13 (38.2)	5 (41.7)
T3	18 (62.1)	10 (58.8)	19 (73.1)	9 (45.0)	21 (61.8)	7 (58.3)
Lymph nodes metastases
No	10 (34.5)	9 (52.9)	3 (11.5)	16 (80.0)a	12 (35.3)	7 (58.3)
Yes	19 (65.5)	8 (47.1)	23 (88.5)	4 (20.0)	22 (64.7)	5 (41.7)
Lauren typing
Intestinal-type	12 (41.4)	6 (35.3)	12 (46.2)	6 (30.0)	13 (38.2)	5 (41.7)
Diffuse-type	9 (31.0)	7 (41.2)	7 (26.9)	9 (45.0)	12 (35.3)	4 (33.3)
Mixed-type	8 (27.6)	4 (23.5)	7 (26.9)	5 (25.0)	9 (26.5)	3 (25.0)

^aP < 0.001.

LILRB2: Leukocyte immunoglobulin-like receptor B2; ANGPTL2: Angiopoietin-like protein 2; HLA-G: Human leukocyte antigen-G; TNM: Tumor-node-metastasis.

Table 2 Correlation between the protein expression levels of leukocyte immunoglobulin-like receptor B2, angiopoietin-like protein 2, and human leukocyte antigen-G, and colony-stimulating factor 3 receptor in gastric cancer tissues by immunohistochemistry, n (%)

		CSF3R
		High	Low
LILRB2	High	29 (85.3)	0 (0.0)
	Low	5 (14.7)	12 (100.0)a
ANGPTL2	High	21 (61.8)	5 (41.7)
	Low	13 (38.2)	7 (58.3)
HLA-G	High	29 (85.3)	5 (41.7)
	Lowa	5 (14.7)	7 (58.3)b

^aP < 0.001.

^bP = 0.01.

LILRB2: Leukocyte immunoglobulin-like receptor B2; ANGPTL2: Angiopoietin-like protein 2; HLA-G: Human leukocyte antigen-G; CSF3R: Colony-stimulating factor 3 receptor.

Table 3 Correlation between the protein expression levels of leukocyte immunoglobulin-like receptor B2, angiopoietin-like protein 2, and human leukocyte antigen-G in gastric cancer tissues by immunohistochemistry, n (%)

		LILRB2
		High	Low
ANGPTL2	High	19 (65.5)	7 (41.2)
	Low	10 (34.5)	10 (58.8)
HLA-G	High	24 (82.8)	10 (58.8)
	Low	5 (17.2)	7 (41.2)

LILRB2: Leukocyte immunoglobulin-like receptor B2; ANGPTL2: Angiopoietin-like protein 2; HLA-G: Human leukocyte antigen-G.