Wang L, Wu Q, Zhang ZW, Zhang H, Jin H, Zhou XL, Liu JY, Li D, Liu Y, Fan ZS. Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer. World J Gastrointest Oncol 2025; 17(2): 97858 [PMID: 39958563 DOI: 10.4251/wjgo.v17.i2.97858]
Corresponding Author of This Article
Zhi-Song Fan, Associate Chief Physician, Associate Professor, MD, PhD, Department of Oncology, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. fanzs@hebmu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Feb 15, 2025; 17(2): 97858 Published online Feb 15, 2025. doi: 10.4251/wjgo.v17.i2.97858
Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer
Long Wang, Qi Wu, Zong-Wen Zhang, Hui Zhang, Hui Jin, Xin-Liang Zhou, Jia-Yin Liu, Dan Li, Yan Liu, Zhi-Song Fan
Long Wang, Qi Wu, Zong-Wen Zhang, Hui Zhang, Hui Jin, Xin-Liang Zhou, Jia-Yin Liu, Dan Li, Yan Liu, Zhi-Song Fan, Department of Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Co-first authors: Long Wang and Qi Wu.
Author contributions: Wang L and Wu Q contributed equally to this article, they are the co-first authors of this manuscript; Fan ZS designed the research study; Fan ZS, Wu Q, and Wang L carried out the entire research; Fan ZS, Wu Q, and Wang L wrote the article; Zhang ZW conducted bioinformatics analysis; Zhang H and Jin H provided guidance and revised the manuscript; Zhou XL, Liu JY, and Li D contributed to the experimental research; and all authors have read and approved the final manuscript.
Supported by Hebei Province Medical Science Research Project Plan, No. 20230755.
Institutional review board statement: The study was reviewed and approved by the Fourth Hospital of Hebei Medical University Institutional Review Board, approval No. 2022KY247.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Song Fan, Associate Chief Physician, Associate Professor, MD, PhD, Department of Oncology, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. fanzs@hebmu.edu.cn
Received: June 11, 2024 Revised: October 29, 2024 Accepted: November 8, 2024 Published online: February 15, 2025 Processing time: 221 Days and 0.4 Hours
Core Tip
Core Tip: This study investigates the relationship between colony-stimulating factor 3 (CSF3)/colony-stimulating factor 3 receptor (CSF3R) and leukocyte immunoglobulin-like receptor B2, along with its ligands angiopoietin-like protein 2 and human leukocyte antigen-G, in gastric cancer (GC). High CSF3R expression correlates with increased levels of leukocyte immunoglobulin-like receptor B2, along with its ligands angiopoietin-like protein 2, and human leukocyte antigen-G in both transcriptomic data and immunohistochemical analysis. CSF3 upregulates these immune checkpoints in GC cells, with heterogeneous nuclear ribonucleoprotein H1 modulating this effect. These findings suggest that the CSF3/CSF3R pathway may play a role in promoting immunosuppression in GC.
