Molecular mechanism of non-coding RNAs-mediated radiosensitivity regulation in colorectal cancer

Table 1 Several microRNAs involved in radiosensitivity of colorectal cancer

MicroRNAs	Target	Radiosensitivity	Ref.
miR-141-3p	DLX6-AS1	Increase	[55]
miR-630	BCL2 L2	Increase	[56]
let-7e	IGF-1R	Increase	[57]
miR-31	STK40	Increase	[58]
miR-124	PRRX1	Increase	[59,60]
miR-378a-5p	LRP8	Increase	[61]
miR-183-5p	ATG5	Decrease	[62]
miR-622	RB1	Decrease	[63]
miR-29a	PTEN	Decrease	[63]
miR-93-5p	FOXA1	Decrease	[64]
miR-19b	FBXW7	Decrease	[65]
miR-106b	PTEN and p21	Decrease	[66]
miR-222	PTEN	Decrease	[67]
miR-4274	PEX5	Increase	[68]
miR-130a	SOX4	Increase	[69]
miR-1226-5p	IRF1	Decrease	[70]

DLX6-AS1: Distal-less homeobox 6 antisense 1; BCL2 L2: BCL2-like 2; IGF-1R: Insulin-like growth factor-1 receptor; STK40: Serine threonine kinase 40; PRRX1: Paired-related homeobox 1; LRP8: Low density lipoprotein receptor related protein 8; ATG5: Autophagy related 5; RB1: RB transcriptional corepressor 1; PTEN: Phosphatase and tensin homolog; FOXA1: Forkhead box protein A1; FBXW7: F-box and WD repeat domain-containing protein 7; p21: Cyclin-dependent kinase inhibitor 1A; PEX5: Peroxisomal biogenesis factor 5; SOX4: SRY-related high-mobility-group box 4; IRF1: Interferon regulatory factor 1.

Table 2 Several long noncoding RNAs involved in radiosensitivity of colorectal cancer

LncRNAs	Target	Radiosensitivity	Ref.
LINC00630	BEX1	Decrease	[20]
lnc-RI	miR-4727-5p and LIG4	Decrease	[71]
HOTAIR	miR-93 and ATR	Decrease	[75-77]
MALAT1	YAP1	Decrease	[78]
TTN-AS1	miR-134-5p	Decrease	[81]
OIP5-AS1	miR-369-3p	Increase	[82]
OTUD6B-AS1	HuR	Increase	[83]
LincRNA-ROR	miR-145	Decrease	[84]
LincRNA-p21	Wnt/β-catenin	Increase	[85]
SP100-AS1	miR-622	Decrease	[86]
UCA1		Decrease	[87]
IGFL2-AS1	AKT pathway	Decrease	[88]

LncRNAs: Long noncoding RNAs; BEX1: Brain expressed X-linked 1; LIG4: DNA ligase 4; ATR: Ataxia-telangiectasia-mutated and Rad3-related protein; YAP1: Yes-associated protein 1; HuR: Human antigen R; AKT: Protein kinase B.

Table 3 Several circular RNAs involved in radiosensitivity of colorectal cancer

CircRNAs	Target	Radiosensitivity	Ref.
circ-MFN2	miR-574-3p	Decrease	[21]
circ_0124554	miR-1184	Decrease	[89]
circ_0006174	miR-940	Decrease	[90]
circBANP	miR-338-3p	Decrease	[91]
circ_0055625	miR-338-3p	Decrease	[92]
circRNA CBL.11	miR-6778-5p	Decrease	[93]
circCCDC66	miR-338-3p	Decrease	[94]
circ_0067835	miR-296-5p	Decrease	[95]
circAFF2	CAND1	Increase	[97]

CircRNAs: Circular RNAs; CAND1: Cullin-associated and neddylation dissociated 1.