Multidimensional decoding of colorectal cancer heterogeneity: Artificial intelligence-enabled precision exploration of single-cell and spatial transcriptomics

Table 1 Clinical trials of colorectal cancer involving single-cell RNA sequencing and spatial transcriptomics

NCT	Date	Name	Organization	Type	Status
NCT04789252	January 02, 2024	Heterogeneity of dendritic cells in colon and non-small cell lung cancer	University of Milano Bicocca	Observational	Recruiting
NCT04622423	October 01, 2024	Advanced therapies for liver metastases	IRCCS San Raffaele	Observational	Recruiting
NCT05056896	December 04, 2024	Aspirin intervention for the reduction of colorectal cancer risk -extension	Massachusetts General Hospital	Interventional	Active, not recruiting
NCT03984578	October 15, 2024	Window of opportunity study in colorectal cancer	National Cancer Centre, Singapore	Interventional	Recruiting
NCT05398380	October 02, 2024	Liver transplantation for non-resectable colorectal liver metastases: Translational research	Hospital Vall d’Hebron	Interventional	Recruiting
NCT06833866	February 19, 2025	Phase I trial of 5-fluorouracil-based therapy in combination with hydroxytyrosol in patients with advanced or metastatic colorectal cancer	The Methodist Hospital Research Institute	Interventional	Recruiting
NCT06886282	March 20, 2025	Spatial radiomics and transcriptomics to the discovery of the cross-link between colon cancer and chronic kidney disease	National Cancer Institute, Naples	Observational	Recruiting
NCT06762405	February 18, 2025	PRODIGE 90-(FFCD 2204) neoadjuvant dostarlimab with short course radiotherapy in a watch-and-wait strategy for microsatellite unstable or mismatch repair-deficient locally advanced rectal cancer patients	Centre Hospitalier Universitaire Dijon	Interventional	Recruiting

NCT: National clinical trial.