Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

doi:10.4251/wjgo.v17.i1.98725

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 1

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (226)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-4) series, Tables (1-3) series.

Item

Count

PDF

HTML

113

Figures (1-4)

Tables (1-3)

Sum=175

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=46

Jan 15, 2025 (publication date) through Dec 24, 2024

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Oncol. Jan 15, 2025; 17(1): 98725
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.98725

Table 1 Comparison of baseline data of patients with gastric cancer, n (%)

Group		Metastases (n = 57)	Absence of metastases (n = 91)	t/χ²	P value
Age (years), mean ± SD		48.61 ± 12.99	48.39 ± 12.16	0.110	0.912
Sex	Male	30 (52.63)	44 (48.35)	0.287	0.591
Sex	Female	27 (47.37)	47 (51.65)	0.287	0.591
BMI (kg/m²), mean ± SD		22.61 ± 2.13	22.42 ± 2.25	0.236	0.814
A family history of malignancy		3 (5.26)	5 (5.49)	0.004	0.952
Present with hypertension		7 (12.28)	12 (13.19)	0.026	0.873
Hyperglycemia		4 (7.02)	10 (10.99)	0.641	0.423
Hyperlipidemia		5 (8.77)	8 (8.79)	< 0.001	0.997
History of alcohol use		12 (19.30)	16 (17.58)	0.273	0.601
Endoscopic tumor site	Cardia (of stomach)	8 (14.04)	17 (18.68)	4.830	0.395
	Fundus of stomach	7 (12.28)	10 (10.99)
	Body of stomach	12 (21.05)	16 (17.58)
	Antrum of stomach	26 (45.61)	47 (51.65)
	Pylorus	2 (3.51)	1 (1.10)
	Whole stomach	2 (3.51)	0 (0.00)
¹⁴C-urea breath test	Masculine	48 (84.21)	72 (79.12)	0.592	0.442
¹⁴C-urea breath test	Feminine character	9 (15.79)	19 (20.88)	0.592	0.442

BMI: Body mass index.

Table 2 Analysis of the correlation of tumor node metastasis stage with coagulation function and fibrinogen degradation products

Index	APTT		PT		TT		AT-Ⅲ		FDP		D-D			FBG
Index	r	P value	r	P value	r	P value	r	P value	r	P value	r	P value	r		P value
TNM staging	0.368	< 0.001	0.437	< 0.001	0.373	< 0.001	0.162	0.050	0.780	< 0.001	0.530	< 0.001	0.329		< 0.001

APTT: Activated partial thromboplastin time; AT-III: Antithrombin III; TT: Thrombin time; PT: Prothrombin time; TNM: Tumor node metastasis; D-D: D-Dimer; FBG: Fibrinogen; FDP: Fibrinogen degradation product.

Table 3 Analysis of the correlation of distant metastasis with coagulation function and fibrinogen degradation products

Index	APTT		PT		TT		AT-Ⅲ		FDP		D-D		FBG
Index	r	P value	r	P value	r	P value	r	P value	r	P value	r	P value	r	P value
Distant metastasis of gastric cancer	0.330	< 0.001	0.451	< 0.001	0.335	< 0.001	0.154	0.062	0.883	< 0.001	0.471	< 0.001	0.316	< 0.001

Citation: Shen YQ, Wei QW, Tian YR, Ling YZ, Zhang M. Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer. World J Gastrointest Oncol 2025; 17(1): 98725
URL: https://www.wjgnet.com/1948-5204/full/v17/i1/98725.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i1.98725