Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 98725
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.98725
Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer
Yi-Qing Shen, Qiu-Wan Wei, Yi-Ren Tian, Yun-Zhi Ling, Min Zhang
Yi-Qing Shen, Qiu-Wan Wei, Yi-Ren Tian, Yun-Zhi Ling, Clinical Laboratory, Civil Aviation Shanghai Hospital, Gubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China
Min Zhang, Clinical Laboratory, Tongji Hospital of Tongji University, Shanghai 200000, China
Co-corresponding authors: Yun-Zhi Ling and Min Zhang.
Author contributions: Shen YQ wrote the manuscript, Wei QW and Tian YR collected and organized data, Ling YZ and Zhang M Designed this research and provided critical feedback on this study. Ling YZ and Zhang M contributed equally to this work and are the co-corresponding authors. First, the research was performed as a collaborative effort, and the designation of co-corresponding authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. This also ensures effective communication and management of post-submission matters, ultimately enhancing the paper's quality and reliability. Second, Ling YZ and Zhang M contributed efforts of equal substance throughout the research process. The choice of these researchers as co-corresponding authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study. In summary, we believe that designating Ling YZ and Zhang M as co-corresponding authors is fitting for our manuscript as it accurately reflects our team's collaborative spirit, equal contributions, and diversity.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the Civil Aviation Shanghai Hospital.
Informed consent statement: All study participants or their legal guardians provided written informed consent for personal and medical data collection before study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used in this study can be obtained from the corresponding author upon request at lyz19840126@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Zhi Ling, MM, Technician, Clinical Laboratory, Civil Aviation Shanghai Hospital, Gubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 398 Hongbaoshi Road, Changning District, Shanghai 200000, China. lyz19840126@163.com
Received: August 28, 2024
Revised: September 30, 2024
Accepted: November 1, 2024
Published online: January 15, 2025
Processing time: 106 Days and 1.5 Hours
Core Tip

Core Tip: Coagulation indices (associations of coagulation indices - partial thromboplastin time, prothrombin time, thrombin time) and fibrinogen degradation products (FDP and D-dimer) are significantly correlated with tumor-node-metastasis stage and distant metastasis in gastric cancer. These biomarkers are indicative of abnormal coagulation and fibrinolytic states and provide essential insights into disease progression. Understanding these associations will enhance diagnostic precision and facilitate the development of personalized treatment strategies for patients with gastric cancer.