Shen YQ, Wei QW, Tian YR, Ling YZ, Zhang M. Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer. World J Gastrointest Oncol 2025; 17(1): 98725 [DOI: 10.4251/wjgo.v17.i1.98725]
Corresponding Author of This Article
Yun-Zhi Ling, MM, Technician, Clinical Laboratory, Civil Aviation Shanghai Hospital, Gubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 398 Hongbaoshi Road, Changning District, Shanghai 200000, China. lyz19840126@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 98725 Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.98725
Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer
Yi-Qing Shen, Qiu-Wan Wei, Yi-Ren Tian, Yun-Zhi Ling, Min Zhang
Yi-Qing Shen, Qiu-Wan Wei, Yi-Ren Tian, Yun-Zhi Ling, Clinical Laboratory, Civil Aviation Shanghai Hospital, Gubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China
Min Zhang, Clinical Laboratory, Tongji Hospital of Tongji University, Shanghai 200000, China
Co-corresponding authors: Yun-Zhi Ling and Min Zhang.
Author contributions: Shen YQ wrote the manuscript, Wei QW and Tian YR collected and organized data, Ling YZ and Zhang M Designed this research and provided critical feedback on this study. Ling YZ and Zhang M contributed equally to this work and are the co-corresponding authors. First, the research was performed as a collaborative effort, and the designation of co-corresponding authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. This also ensures effective communication and management of post-submission matters, ultimately enhancing the paper's quality and reliability. Second, Ling YZ and Zhang M contributed efforts of equal substance throughout the research process. The choice of these researchers as co-corresponding authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study. In summary, we believe that designating Ling YZ and Zhang M as co-corresponding authors is fitting for our manuscript as it accurately reflects our team's collaborative spirit, equal contributions, and diversity.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the Civil Aviation Shanghai Hospital.
Informed consent statement: All study participants or their legal guardians provided written informed consent for personal and medical data collection before study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used in this study can be obtained from the corresponding author upon request at lyz19840126@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Zhi Ling, MM, Technician, Clinical Laboratory, Civil Aviation Shanghai Hospital, Gubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 398 Hongbaoshi Road, Changning District, Shanghai 200000, China. lyz19840126@163.com
Received: August 28, 2024 Revised: September 30, 2024 Accepted: November 1, 2024 Published online: January 15, 2025 Processing time: 106 Days and 1.5 Hours
Abstract
BACKGROUND
Gastric cancer (GC) is a prevalent malignancy with a substantial health burden and high mortality rate, despite advances in prevention, early detection, and treatment. Compared with the global average, Asia, notably China, reports disproportionately high GC incidences. The disease often progresses asymptomatically in the early stages, leading to delayed diagnosis and compromised outcomes. Thus, it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce mortality.
AIM
To investigate coagulation and fibrinogen products in GC tumor-node-metastasis (TNM) stage and metastasis correlation.
METHODS
Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December 2023. The associations of coagulation indices - partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen, fibrinogen degradation products (FDP), fasting blood glucose, and D-dimer (D-D) with TNM stage and distant metastasis were examined.
RESULTS
Prolongation of APTT, PT, and TT was significantly correlated with the GC TNM stage. Hence, abnormal coagulation system activation was closely related to disease progression. Elevated FDP and D-D were significantly associated with distant metastasis in GC (P < 0.05), suggesting that increased fibrinolytic activity contributes to increased metastatic risk.
CONCLUSION
Our Results reveal coagulation indices, FDPs as GC biomarkers, reflecting abnormal coagulation/fibrinolysis, aiding disease progression, metastasis prediction, and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.
Core Tip: Coagulation indices (associations of coagulation indices - partial thromboplastin time, prothrombin time, thrombin time) and fibrinogen degradation products (FDP and D-dimer) are significantly correlated with tumor-node-metastasis stage and distant metastasis in gastric cancer. These biomarkers are indicative of abnormal coagulation and fibrinolytic states and provide essential insights into disease progression. Understanding these associations will enhance diagnostic precision and facilitate the development of personalized treatment strategies for patients with gastric cancer.
