Comparison of mismatch repair and immune checkpoint protein profile with histopathological parameters in pancreatic, periampullary/ampullary, and choledochal adenocarcinomas

Table 1 Comparison of H long terminal repeat-associating 2 expression and clinicopathological parameters

		Cytoplasmic HHLA2 expression			P value1
		Negative, n (%)	Low, n (%)	High, n (%)
Gender	Male	7 (63.64)	48 (75.00)	9 (52.94)	0.193
	Female	4 (36.36)	16 (25.00)	8 (47.06)
Pathologic stage of tumor	T1	0 (0.00)	0(.00)	3(17.65)	0.011
	T2	4 (36.36)	23(35.94)	8(47.06)
	T3	7 (63.64)	38(59.38)	5(29.41)
	T4	0 (0.00)	3(4.69)	1(5.88)
Lymphovascular invasion	Present	1 (9.09)	8(12.50)	2(11.76)	0.949
	Absent	10 (90.91)	56(87.50)	15(88.24)
Perineural invasion	Present	0 (0.00)	2 (3.13)	3 (17.65)	0.044
	Absent	11 (100.00)	62 (96.88)	14 (82.35)
Histologic grade	Poorly	2 (18.18)	11 (17.19)	3 (17.65)	0.901
	Moderately	7 (63.64)	41 (64.06)	9 (52.94)
	Well	2 (18.18)	12 (18.75)	5 (29.41)
Tumor stroma ratio	Low	4 (36.36)	33 (51.56)	9 (52.94)	0.625
	High	7 (63.64)	31 (48.44)	8 (47.06)
Diameter of tumor (cm)3		3.11 ± 1.25 (3.00)	3.65 ± 1.24 (4.00)	2.94 ± 1.03 (3.00)	0.0882
Tumor budding degree		2.45 ± 0.82 (3.00)	2.48 ± 0.80 (3.00)	1.88 ± 1.05 (2.00)	0.0532
Age4		59.91 ± 6.33 (60.00)	65.38 ± 8.28 (66.00)	69.65 ± 8.77 (72.00)	0.0052

¹Chi-Square test.

²Kruskal Wallis test.

³mean ± SD is given instead of n.

⁴mean ± SD is given instead of %.