Occult intestinal angiosarcoma presenting as refractory anemia during tyrosine kinase inhibitor therapy for chronic myeloid leukemia: A case report

doi:10.4251/wjgo.v18.i4.116365

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Apr 15, 2026 (publication date) through Apr 11, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Apr 15, 2026; 18(4): 116365
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116365

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Figure 1 Video capsule endoscopy images. A: Minor bleeding at the level of the esophagus; B: Multiple blood clots in the proximal jejunum.

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Figure 2 Resected jejunal segment showing two hemorrhagic polypoid tumors, one marked with a hemostatic clip.

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Figure 3 Histological examination of the surgical specimen. A: Hematoxylin and eosin (HE) stain, medium magnification (×20); B: HE stain, high magnification (×40); C: Immunohistochemical staining for cytokeratin; D: Immunohistochemical staining for ERG.

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Figure 4 Patient trajectory from presentation to diagnosis. MMR: Major molecular response; Hb: Hemoglobin; CT: Computed tomography.

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Figure 5 Magnetic resonance images from December 2024 and January 2025. A: Axial magnetic resonance imaging (magnetic resonance imaging [MRI]; December 16, 2024): Right hemispheric nodular lesions (0.5 cm and 0.6 cm), no contrast enhancement pre- or post-contrast; B: Axial MRI (January 23, 2025): Marked lesion enlargement (2.0 cm and 2.5 cm) with minimal contrast enhancement.

Citation: Najdi T, Seif S, Khoury D, Kahwagi A, Wehbe P, Karam R, El Halabi L, Slim R, Chakhtoura G, Trak V, Eid R. Occult intestinal angiosarcoma presenting as refractory anemia during tyrosine kinase inhibitor therapy for chronic myeloid leukemia: A case report. World J Gastrointest Oncol 2026; 18(4): 116365
URL: https://www.wjgnet.com/1948-5204/full/v18/i4/116365.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i4.116365