Hepatocellular carcinoma in F0 livers: Clinical and prognostic insights

doi:10.4251/wjgo.v18.i4.115576

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Apr 15, 2026 (publication date) through Apr 11, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Apr 15, 2026; 18(4): 115576
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115576

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Figure 1 Overall survival and recurrence-free survival of patients with F0 and F4 hepatocellular carcinoma. A: Overall survival. Kaplan-Meier analysis showed no significant difference in overall survival between F0 (nonfibrotic liver) and F4 (cirrhotic liver) hepatocellular carcinoma (P = 0.789); B: Recurrence-free survival. Recurrence was seen in 22 patients and 73 patients, respectively, in the F0 and F4 hepatocellular carcinoma groups, although recurrence-free survival was comparable between both groups based on the Kaplan-Meier curves (P = 0.116). HCC: Hepatocellular carcinoma.

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Figure 2 Comparison of overall survival based on recurrence status. A: Among patients with F0 hepatocellular carcinoma, those with recurrence had significantly shorter overall survival (P = 0.001); B: Among patients with F4 hepatocellular carcinoma, overall survival was similar regardless of the presence of recurrence (P = 0.830).

Citation: Endo M, Honda K, Tokumaru T, Saito T, Uchida T, Iwao M, Arakawa M, Seike M, Kodama M, Masuda T, Endo Y, Inomata M, Murakami K, Mizukami K. Hepatocellular carcinoma in F0 livers: Clinical and prognostic insights. World J Gastrointest Oncol 2026; 18(4): 115576
URL: https://www.wjgnet.com/1948-5204/full/v18/i4/115576.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i4.115576