Clinical and endoscopic characteristics of early gastric signet ring cell carcinoma based on Helicobacter pylori infection status

Figure 1 Endoscopic of early gastric signet ring cell carcinoma under white light, linked color imaging, narrow-band imaging, blue laser imaging, magnifying endoscopy and typical pathological images. A: A 18 mm type 0-IIa + IIc lesion located at the lesser curvature of the lower gastric body showed reddish roughness with Helicobacter pylori (H. pylori) infection under white light; B: Narrow-band imaging-magnifying endoscopy showed the irregular microsurface pattern (MSP) and enlarged intervening part (IP) of lesion A; C: A 20 mm type 0-IIb lesion located at the greater curvature of the lower gastric body showed localized intermixed reddish-yellowish area and discoloration with H. pylori eradication under linked color imaging; D: Blue laser imaging-magnifying endoscopy (BLI-ME) showed the irregular MSP, irregular microvascular pattern (MVP) and enlarged IP of lesion C; E: A 10 mm type 0-IIb lesion located at the greater curvature of the lower gastric body showed discoloration with H. pylori-uninfected status under white light; F: BLI-ME showed the irregular MSP, irregular MVP and enlarged IP of lesion E; G: Microscopic appearance with hematoxylin-eosin staining (× 200); H: Confirmation of the diagnosis with immunohistochemical staining being positive for CK (× 200).