Cancer-associated fibroblasts, clinicopathological characteristics and prognosis of liver cancer: A systematic review and meta-analysis based on real-world research

doi:10.4251/wjgo.v17.i12.110395

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Dec 15, 2025; 17(12): 110395
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.110395

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Figure 1 Flowchart and selection process of eligible studies.

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Figure 2 Pooled hazard ratios of cancer-associated fibroblast expression for overall survival in liver cancer patients. CAF: Cancer-associated fibroblast; HCC: Hepatocellular carcinoma; iCCA: Intrahepatic cholangiocarcinoma; HR: Hazard ratio; CI: Confidence interval.

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Figure 3 Pooled risk ratios of cancer-associated fibroblast expression for clinicopathological characteristics in liver cancer patients. A: Tumor size; B: Venous infiltration; C: Tumor-node-metastasis stage; D: Alpha-fetoprotein level; E: Tumor differentiation. CAF: Cancer-associated fibroblast; LC: Liver cancer; HCC: Hepatocellular carcinoma; iCCA: Intrahepatic cholangiocarcinoma; OR: Odds ratio; CI: Confidence interval.

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Figure 4 Forest plots of the impact of smooth muscle actin expression on clinicopathological characteristics and overall survival in liver cancer patients. A: Venous infiltration; B: Tumor-node-metastasis stage; C: Overall survival. SMA: Smooth muscle actin; LC: Liver cancer; HCC: Hepatocellular carcinoma; iCCA: Intrahepatic cholangiocarcinoma; OR: Odds ratio; CI: Confidence interval.

Citation: Wei YH, Jiang WJ, Wang SQ, Cai YL, Ma XL. Cancer-associated fibroblasts, clinicopathological characteristics and prognosis of liver cancer: A systematic review and meta-analysis based on real-world research. World J Gastrointest Oncol 2025; 17(12): 110395
URL: https://www.wjgnet.com/1948-5204/full/v17/i12/110395.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i12.110395