Stromal secreted protein acidic and rich in cysteine expression: A potential target for improved prognosis in patients with pancreatic cancer

Figure 1 Representative immunohistochemical secreted protein acidic and rich in cysteine staining intensity in the cancer component (× 100, scale bar: 300 μm). This figure is provided as a representative case without quantitative statistical comparison. A: Secreted protein acidic and rich in cysteine (SPARC) cancer negative (0); B: SPARC cancer weak (1); C: SPARC cancer moderate (2); D: SPARC cancer strong (3).

Figure 2 Representative immunohistochemical secreted protein acidic and rich in cysteine staining in the stromal component (× 100, scale bar: 300 μm). This figure is provided as a representative case without quantitative statistical comparison. A: Stromal negative secreted protein acidic and rich in cysteine; B: Stromal positive secreted protein acidic and rich in cysteine.

Figure 3 Representative immunohistochemical staining of secreted protein acidic and rich in cysteine in the cancer and stromal components combination (× 100, scale bar: 300 μm). This figure is provided as a representative case without quantitative statistical comparison. A: Secreted protein acidic and rich in cysteine (SPARC) stroma (+) and SPARC cancer (+); B: SPARC stroma (+) and SPARC cancer (-); C: SPARC stroma (-) and SPARC cancer (+); D: SPARC stroma (-) and SPARC cancer (-).

Figure 4 Survival analysis according to secreted protein acidic and rich in cysteine expression in stroma and cancer cell of resected pancreatic tissue. A: Overall survival difference according to secreted protein acidic and rich in cysteine expression in cancer tissue; B: Overall survival difference according to secreted protein acidic and rich in cysteine expression in stroma of the tumor. SPARC: Secreted protein acidic and rich in cysteine.

Figure 5 Overall survival difference. A: According to secreted protein acidic and rich in cysteine expression in stroma and cancer cells; B: According to secreted protein acidic and rich in cysteine expression and postoperative adjuvant chemotherapy. P indicates Bonferroni-corrected P value. ^aP < 0.05 was considered statistically significant. AdjuCTx: Adjuvant chemotherapy.