©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2016; 8(8): 635-641
Published online Aug 15, 2016. doi: 10.4251/wjgo.v8.i8.635
Published online Aug 15, 2016. doi: 10.4251/wjgo.v8.i8.635
Utility of different serum fibrosis markers in diagnosing patients with chronic pancreatitis and pancreatic adenocarcinoma
Anna Kozak, Renata Talar-Wojnarowska, Aleksandra Kaczka, Ewa Małecka-Panas, Anita Gąsiorowska, Department of Digestive Tract Diseases, Medical University of Lodz, 90-153 Lodz, Poland
Anna Borkowska, Leszek Czupryniak, Department of Diabetology and Metabolic Diseases, Medical University of Lodz, 92-213 Lodz, Poland
Author contributions: Kozak A performed the systematic search of the literature, conducted statistical analysis and wrote the manuscript; Talar-Wojnarowska R, Kaczka A and Czupryniak L contributed equally to the acquisition and analysis of data; Borkowska A carried out the laboratory part of the project; Małecka-Panas E revised the article critically; Gąsiorowska A designed the study and reviewed the final version of the text.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the Medical University of Lodz (RNN/146/15/KE).
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors declare no potential conflicting interests related to this paper.
Data sharing statement: No additional data are available.
Correspondence to: Kozak Anna, MD, Department of Digestive Tract Diseases, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, Poland. annak.kozak@gmail.com
Telephone: +48-426-776667 Fax: +48-678-6480
Received: February 1, 2016
Peer-review started: February 2, 2016
First decision: March 14, 2016
Revised: May 21, 2016
Accepted: June 14, 2016
Article in press: June 16, 2016
Published online: August 15, 2016
Processing time: 189 Days and 15.8 Hours
Peer-review started: February 2, 2016
First decision: March 14, 2016
Revised: May 21, 2016
Accepted: June 14, 2016
Article in press: June 16, 2016
Published online: August 15, 2016
Processing time: 189 Days and 15.8 Hours
Core Tip
Core tip: Fibrosis begins in an early stage of the disease in chronic pancreatitis and in pancreatic ductal adenocarcinoma. Cytokines such as transforming growth factor beta-1, hyaluronic acid, soluble fractalkine and monocyte chemoattractant protein-1 take part in connective tissue proliferation. It is essential to diagnose pancreatic diseases in the early stage in order to start an appropriate therapy. Cytokines can be useful clinical biomarkers.