Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Sep 15, 2026; 18(9): 120033
Published online Sep 15, 2026. doi: 10.4251/wjgo.120033
Published online Sep 15, 2026. doi: 10.4251/wjgo.120033
Letter to the Editor: Programmed death-1/programmed death-ligand 1 inhibitors in the treatment of elderly patients with advanced pancreatic cancer
Yan Feng, Department of Gastroenterology, The Affiliated Hospital of Panzhihua University, Panzhihua 61700, Sichuan Province, China
Hai-Wei Yu, Ke Xu, Department of Oncology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Hai-Wei Yu, Department of Pharmacy, HIV/AIDS Clinical Treatment Center of Guangxi (Nanning) and The Fourth People’s Hospital of Nanning, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Ke Xu, School of clinical Medical, Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Author contributions: Feng Y and Yu HW were responsible for data curation and writing original draft; Xu K was responsible for investigation, writing review and editing, validation, and supervision; all of the authors contributed to conceptualization and methodology, and have read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Ke Xu, MD, Department of Oncology, The First Affiliated Hospital of Chengdu Medical College, No. 278 Baoguang Street, Xindu District, Chengdu 610500, Sichuan Province, China. xuke@cmc.edu.cn
Received: February 13, 2026
Revised: March 2, 2026
Accepted: April 13, 2026
Published online: September 15, 2026
Processing time: 194 Days and 4.8 Hours
Revised: March 2, 2026
Accepted: April 13, 2026
Published online: September 15, 2026
Processing time: 194 Days and 4.8 Hours
Core Tip
Core Tip: The recent study by Lu et al identified Eastern Cooperative Oncology Group performance status, prognostic nutritional index, and triglyceride levels as independent predictors for progression-free survival and overall survival in elderly patients with advanced pancreatic cancer receiving programmed death-1 inhibitors. While the results still need further verification, this work provides important clues in this underexplored research domain.