Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Jul 15, 2026; 18(7): 119170
Published online Jul 15, 2026. doi: 10.4251/wjgo.v18.i7.119170
Published online Jul 15, 2026. doi: 10.4251/wjgo.v18.i7.119170
Impact of anxiety and depression on quality of life in gastric cancer patients receiving SOX neoadjuvant chemotherapy
Bo-Yang Cui, School of Psychology, Fujian Normal University, Fuzhou 350000, Fujian Province, China
Zhen Zhang, Department of Thoracic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, Yunnan Province, China
Author contributions: Cui BY and Zhang Z contributed to the study conception and design; Zhang Z performed analysis, material preparation, data collection; Cui BY was written the first draft of the manuscript. Cui BY and Zhang Z critically revised and approved the final version of the manuscript.
AI contribution statement: In this manuscript, we only use Grammarly and DeepL for English polishing and translation assistance. No AI tools were used to generate any parts of the main text, design research, interpret results, or generate images.
Institutional review board statement: This study was reviewed and approved by Medical Ethics Committee of the Second Affiliated Hospital of Kunming Medical University.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: No conflict of interest is associated with this work.
Data sharing statement: No other data available.
Corresponding author: Zhen Zhang, Lecturer, Department of Thoracic Surgery, The Second Affiliated Hospital of Kunming Medical University, No. 374 Dianmian Avenue, Wuhua District, Kunming 650000, Yunnan Province, China. 15987129313@163.com
Received: January 20, 2026
Revised: February 3, 2026
Accepted: March 10, 2026
Published online: July 15, 2026
Processing time: 166 Days and 17.9 Hours
Revised: February 3, 2026
Accepted: March 10, 2026
Published online: July 15, 2026
Processing time: 166 Days and 17.9 Hours
Core Tip
Core Tip: This study reveals that nearly half of the patients with early-to-mid-stage gastric cancer undergoing neoadjuvant chemotherapy experience anxiety or depression. These conditions are more common in females, those without spousal support, the less educated, and those with advanced-stage disease. Critically, psychological distress is independently linked to more severe gastrointestinal reactions and a significantly poorer quality of life. Our findings underscore the urgent need for integrating routine psychological screening and support into the standard management protocol for these patients to address both mental and physical well-being.