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World J Gastrointest Oncol. Jul 15, 2026; 18(7): 118372
Published online Jul 15, 2026. doi: 10.4251/wjgo.v18.i7.118372
Published online Jul 15, 2026. doi: 10.4251/wjgo.v18.i7.118372
Association between geriatric nutritional risk index and colorectal adenoma risk in an asymptomatic screening population
Xue-Yan Niu, Dan Wang, Fei Chen, Yi-Zhe Yang, Kai Meng, Yang-Xuan Du, Department of General Practice, Shanghai Jing’an District Zhabei Center Hospital, Shanghai 200070, China
Bin Liu, Endoscope Room, Shanghai Electric Power Hospital, Shanghai 200050, China
Co-first authors: Xue-Yan Niu and Dan Wang.
Author contributions: Niu XY and Wang D contributed to the research design, data collection, and manuscript writing and revision, they contributed equally to this article, they are the co-first authors of this manuscript; Chen F, Yang YZ, Meng K, and Du YX assisted in data collection and literature review; Liu B coordinated the research, revised the final manuscript, and handled academic communication; and all authors have approved the final manuscript and confirmed its ethical compliance.
Supported by the Discipline Construction Project (Cultivating Discipline) of Jing’an District, Shanghai, No. 2021PY02.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Shanghai Jing’an District Zhabei Center Hospital, approval No. ZBLL2025121801001.
Informed consent statement: All patients signed informed consent forms before the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No other data provided.
Corresponding author: Bin Liu, Associate Chief Physician, Endoscope Room, Shanghai Electric Power Hospital, No. 937 Yan’an West Road, Shanghai 200050, China. liubin71@gt.cn
Received: January 30, 2026
Revised: March 3, 2026
Accepted: April 7, 2026
Published online: July 15, 2026
Processing time: 157 Days and 0.4 Hours
Revised: March 3, 2026
Accepted: April 7, 2026
Published online: July 15, 2026
Processing time: 157 Days and 0.4 Hours
Core Tip
Core Tip: This health screening-based cohort study demonstrates that the geriatric nutritional risk index (GNRI) effectively stratifies the risk of colorectal premalignant lesions in asymptomatic adults. With an optimal cutoff of 95.6, the GNRI predicted adenoma occurrence with high accuracy (area under the curve = 0.874), outperforming individual measurements of serum albumin or body mass index. Lower GNRI values were independently associated with increased adenoma detection rates and advanced histology, supporting the use of the GNRI as a simple, noninvasive tool for prioritizing high-risk individuals for gastrointestinal tumor surveillance.