Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Jul 15, 2026; 18(7): 118212
Published online Jul 15, 2026. doi: 10.4251/wjgo.v18.i7.118212
Published online Jul 15, 2026. doi: 10.4251/wjgo.v18.i7.118212
Long-term survival after combined hepatectomy and colectomy for ruptured combined hepatocellular-cholangiocarcinoma with direct colonic invasion: A case report
Chong-Wei Yang, Ri-Xin Zhang, Xiao-Lin Zheng, Ling Zhu, Zhi Zheng, Xin-Hua Wu, Department of Hepatobiliary Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China
Chong-Wei Yang, Ri-Xin Zhang, Xiao-Lin Zheng, Ling Zhu, Zhi Zheng, Xin-Hua Wu, Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China
Co-first authors: Chong-Wei Yang and Ri-Xin Zhang.
Co-corresponding authors: Zhi Zheng and Xin-Hua Wu.
Author contributions: Yang CW collected the data and drafted the manuscript; Zhang RX performed the surgery and revised the manuscript; Yang CW and Zhang RX contributed equally to this article, they are the co-first authors of this manuscript; Zheng XL performed the surgery and clarified the treatment plan for the patient; Zhu L clarified the final treatment plan and supervised the study; Zheng Z revised the manuscript, provided financial support and is the corresponding author responsible for journal communication; Wu XH revised the manuscript, conducted data analysis; Zheng Z and Wu XH contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors have read and approved the final manuscript.
AI contribution statement: We used AI tools (including Doubao and DeepSeek) during manuscript preparation. AI tools were only used for language polishing, translation, and writing assistance, not for data analysis.
Informed consent statement: Informed written consent was obtained from the patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Zhi Zheng, MD, Chief Doctor, Department of Hepatobiliary Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang’an District, Wuhan 430014, Hubei Province, China.
Received: December 29, 2025
Revised: February 25, 2026
Accepted: April 1, 2026
Published online: July 15, 2026
Processing time: 192 Days and 5.5 Hours
Revised: February 25, 2026
Accepted: April 1, 2026
Published online: July 15, 2026
Processing time: 192 Days and 5.5 Hours
Core Tip
Core Tip: This study reports a successful case of staged multidisciplinary management for a life-threatening ruptured liver cancer with direct colonic invasion, pathologically confirmed as combined hepatocellular cholangiocarcinoma, a rare and aggressive histological subtype. The strategy involved initial embolization, followed by combined organ resection and modern adjuvant therapy, achieving over 42 months of long-term survival. The key finding is that tumor rupture should not be considered an absolute contraindication to curative treatment, and that aggressive surgical resection integrated with modern multimodal therapy can significantly improve outcomes even in such advanced cases.