Wang QJ, Gao JN, Wu PT, Lu GR, Xu XZ. Moderately to poorly differentiated adenocarcinoma invading a leiomyoma: A case report. World J Gastrointest Oncol 2026; 18(6): 118708 [DOI: 10.4251/wjgo.v18.i6.118708]
Corresponding Author of This Article
Xian-Zuo Xu, Department of Gastroenterology, The Third People’s Hospital of Cangnan County, No. 188 Wenxin Road, Qianku Town, Cangnan County, Wenzhou 325000, Zhejiang Province, China. 13706653410@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
case-report
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Wang QJ, Gao JN, Wu PT, Lu GR, Xu XZ. Moderately to poorly differentiated adenocarcinoma invading a leiomyoma: A case report. World J Gastrointest Oncol 2026; 18(6): 118708 [DOI: 10.4251/wjgo.v18.i6.118708]
Qin-Jian Wang, Jia-Ni Gao, Ping-Ting Wu, Guang-Rong Lu, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Xian-Zuo Xu, Department of Gastroenterology, The Third People’s Hospital of Cangnan County, Wenzhou 325000, Zhejiang Province, China
Co-first authors: Qin-Jian Wang and Jia-Ni Gao.
Author contributions: Wang QJ, Gao JN, and Wu PT contributed to manuscript writing and editing; Wang QJ and Gao JN contributed equally to this article, they are the co-first authors of this manuscript; Lu GR and Xu XZ contributed to conceptualization and critical revisions; and all authors have read and approved the final manuscript.
AI contribution statement: Regarding the writing process of the manuscript and the use of AI tools, I would like to make the following explanations: (1) During the writing process of the manuscript, I only used translation tools such as DeepL, and did not use AI tools such as ChatGPT; (2) The main body of the paper (abstract, introduction, materials and methods, results, discussion and conclusion) has not been generated using AI tools; (3) Only DeepL was used to translate and polish some sentences, without using AI tools to analyze data or assist in manuscript writing; (4) AI tools were not involved in the design of the research or the interpretation of the results; and (5) All images are real medical records of the patients and no images were generated using AI.
Supported by Wenzhou Science and Technology Bureau, No. Y20240207.
Informed consent statement: Written informed consent was obtained from the patient prior to the initiation of any medical interventions and data collection.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Xian-Zuo Xu, Department of Gastroenterology, The Third People’s Hospital of Cangnan County, No. 188 Wenxin Road, Qianku Town, Cangnan County, Wenzhou 325000, Zhejiang Province, China. 13706653410@163.com
Received: January 12, 2026 Revised: February 3, 2026 Accepted: March 17, 2026 Published online: June 15, 2026 Processing time: 148 Days and 14.9 Hours
Core Tip
Core Tip: Gastric collision tumors featuring adenocarcinoma invading leiomyoma are extremely rare, posing diagnostic and therapeutic challenges. This case describes a 59-year-old male with recurrent abdominal bloating, diagnosed via a multimodal approach: Gastroscopy, endoscopic ultrasound, contrast-enhanced computed tomography, histopathology, and immunohistochemistry. Immunohistochemistry (smooth muscle actin, desmin positivity for leiomyoma; cytokeratin-pan positivity for adenocarcinoma) was pivotal for definitive diagnosis. Endoscopic submucosal dissection (ESD) achieved en bloc resection with uneventful recovery and no recurrence at 8-month follow-up. Notably, the benign leiomyoma may have constrained malignant invasion, facilitating ESD feasibility. This report underscores the necessity of comprehensive diagnostics and supports ESD as a minimally invasive option for localized lesions, warranting further research on the tumor-stroma interaction.
