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World J Gastrointest Oncol. May 15, 2026; 18(5): 117580
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117580
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117580
Characteristics and prognosis of primary gastric adenosquamous carcinoma: A multicenter retrospective study based on propensity score matching
Yi-Wen Chen, Zhong-Yi Dong, Hao-Yu Zhang, Xiang Xia, Department of Gastrointestinal Surgery, Renji Hospital, Shanghai 200127, China
Xin-Xin Wang, Lin Chen, Department of General Surgery, First Medical Centre of Chinese PLA General Hospital, Beijing 100853, China
Yi Cao, Zheng-Rong Li, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Nanchang University, Nanchang 330006, Jiangxi Province, China
Jian-Xian Lin, Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 35000, Fujian Province, China
Hao Chen, Division of Gastrointestinal Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Yong-Biao Xiao, Department of Gastrointestinal Surgery, The First People’s Hospital of Kashgar, Kashgar 844000, Xinjiang Uygur Autonomous Region, China
Guo-Xin Li, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Zi-Zhen Zhang, Department of Gastrointestinal Surgery, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Co-first authors: Yi-Wen Chen and Zhong-Yi Dong.
Co-corresponding authors: Xiang Xia and Zi-Zhen Zhang.
Author contributions: Zhang ZZ, Xia X, Chen L, Zheng CH, Li ZR, and Li GX designed the research study; Chen YW and Dong ZY performed the research, analyzed the data, and wrote the manuscript; Wang XX, Cao Y, Lin JX, Chen H, Zhang HY, and Xiao YB collected the data and provided clinical resources; all authors read and approved the final manuscript; Zhang ZZ had full access to all data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis; Chen YW and Dong ZY contributed equally to this work as co-first authors; both authors played critical roles in the acquisition of multicenter clinical data, performed the propensity score matching and statistical analysis, and collaborated closely on drafting and revising the manuscript; Zhang ZZ and Xia X contributed equally to this work as co-corresponding authors; the authors jointly conceptualized the study design, secured funding support, and supervised the entire research process and were responsible for the final review and critical revision of the manuscript for important intellectual content.
Supported by the Science and Technology Commission of Shanghai Municipality, No. 25SF1905600; and National Natural Science Foundation of China, No. 82303428, No. 82473077 and No. 82473065.
Institutional review board statement: This study was approved by the Ethics Committee of the Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (approval No. KY2022-084-B).
Informed consent statement: The need for informed consent was waived by the Ethics Committee of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine because of the retrospective nature of the study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: All data generated during this study are included in this published article/Supplementary material. The anonymized raw data that support the findings of this study are available from the corresponding author upon reasonable request.
Corresponding author: Zi-Zhen Zhang, MD, Professor, Department of Gastrointestinal Surgery, School of Medicine, Shanghai Jiao Tong University, No. 160 Pu Jian Road, Shanghai 200127, China. zhangzizhen@renji.com
Received: December 11, 2025
Revised: January 12, 2026
Accepted: February 24, 2026
Published online: May 15, 2026
Processing time: 155 Days and 0.6 Hours
Revised: January 12, 2026
Accepted: February 24, 2026
Published online: May 15, 2026
Processing time: 155 Days and 0.6 Hours
Core Tip
Core Tip: This multicenter retrospective study represents the largest Eastern cohort of patients with primary gastric ade