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World J Gastrointest Oncol. Mar 15, 2026; 18(3): 117083
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.117083
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.117083
Dietary factors in Helicobacter pylori-negative early gastric cancer: Risk, protection, and mechanistic insights
Di Fan, Anesthesia Recovery Room, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Rui-Jia Li, Chu-Yan Guo, Department of Gastrointestinal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Jiao Y and Fan D contributed to conceptualization; Fan D, Guo CY, and Li RJ contributed to the writing of the original draft; Jiao Y contributed to the methodology, revised the manuscript, and supervised the study; Guo CY and Li RJ contributed to the literature review and assisted in formal analysis and visualization. All authors approved the final version to publish.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. jiaoyan@jlu.edu.cn
Received: November 28, 2025
Revised: December 14, 2025
Accepted: January 4, 2026
Published online: March 15, 2026
Processing time: 104 Days and 18 Hours
Revised: December 14, 2025
Accepted: January 4, 2026
Published online: March 15, 2026
Processing time: 104 Days and 18 Hours
Core Tip
Core Tip: Diet plays a critical role in the development of Helicobacter pylori (H. pylori)-negative early gastric cancer. High salt intake and processed foods increase carcinogenic risk, while fruits, vegetables, antioxidants, dietary fiber, and Mediterranean-style dietary patterns provide protective effects independent of H. pylori status. Understanding these dietary influences is essential for improving prevention strategies and refining risk assessment in H. pylori-negative populations.